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Literature summary for 1.5.8.3 extracted from

  • Chen, X.; Overcash, R.; Green, T.; Hoffman, D.; Asch, A.S.; Ruiz-Echevarria, M.J.
    The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels (2011), J. Biol. Chem., 286, 16091-16100.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
TMEFF2 i.e. full-length follistatin motifs 2, the enzyme interacts with the full-length follistatin motifs 2, TMEFF2. TMEFF2 has a dual mode of action. The ectodomain does not bind to SARDH. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. Expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of Myc- and His-tagged enzyme in HEK-293T cells, co-exxpression with TMEFF2, phenotype, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sarcosine + H2O + electron-transfer flavoprotein Homo sapiens
-
glycine + formaldehyde + reduced electron-transfer flavoprotein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
prostate
-
Homo sapiens
-
prostate gland cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sarcosine + H2O + electron-transfer flavoprotein
-
Homo sapiens glycine + formaldehyde + reduced electron-transfer flavoprotein
-
?

Synonyms

Synonyms Comment Organism
SARDH
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
electron transferring flavoprotein
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens overexpression of TMEFF2 activates the enzyme activity but does not affect its expression level additional information

General Information

General Information Comment Organism
metabolism TMEFF2 interacts with SARDH and regulates the cellular levels of sarcosine. The tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine Homo sapiens
additional information the enzyme interacts with the full-length follistatin motifs 2, TMEFF2. TMEFF2 has a dual mode of action. The ectodomain does not bind to SARDH. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. Expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells Homo sapiens