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Literature summary for 1.5.5.3 extracted from

  • Li, X.; Knight, J.; Fargue, S.; Buchalski, B.; Guan, Z.; Inscho, E.W.; Liebow, A.; Fitzgerald, K.; Querbes, W.; Todd Lowther, W.; Holmes, R.P.
    Metabolism of (13)C5-hydroxyproline in mouse models of primary hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase (2016), Biochim. Biophys. Acta, 1862, 233-239 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.5.3

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-4-hydroxy-L-proline + a quinone Mus musculus
-
 (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-4-hydroxy-L-proline + a quinone
-
 Mus musculus (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol
-
 ?

Synonyms

Synonyms Comment Organism
HPOX
-
 Mus musculus
HYPDH
-
 Mus musculus
ProDH2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockdown alters glycolate and oxalate levels Mus musculus