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Literature summary for 1.5.5.2 extracted from

  • Schertl, P.; Cabassa, C.; Saadallah, K.; Bordenave, M.; Savoure, A.; Braun, H.P.
    Biochemical characterization of proline dehydrogenase in Arabidopsis mitochondria (2014), FEBS J., 281, 2794-2804 .
    View publication on PubMed
Search for more literature for 1.5.5.2

Inhibitors

Inhibitors Comment Organism Structure
D-lactate a competitive inhibitor of ProDH in plants Arabidopsis thaliana
L-lactate a competitive inhibitor of ProDH in plants Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion transcriptional induction of the enzyme causes changes in expression levels of other mitochondrial enzymes. Activity of glutamate dehydrogenase is substantially increased, and activity of D-lactate dehydrogenase is increased Arabidopsis thaliana 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-proline + oxidized phenazine methosulfate Arabidopsis thaliana
-
 (S)-1-pyrroline-5-carboxylate + reduced phenazine methosulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-proline + 2,6-dichlorphenol-indophenol
-
 Arabidopsis thaliana (S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorphenol-indophenol
-
 ?
L-proline + oxidized phenazine methosulfate
-
 Arabidopsis thaliana (S)-1-pyrroline-5-carboxylate + reduced phenazine methosulfate
-
 ?

Subunits

Subunits Comment Organism
? x * 55000-57000, SDS-PAGE Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
PRODH
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Arabidopsis thaliana
phenazine methosulfate
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana L-proline treatment induces ProDH in planta. Induction of D-lactate dehydrogenase activity allows rapid upregulation of ProDH activity during the short-term stress response in plants. Transcriptional induction of the enzyme causes changes in expression levels of other mitochondrial enzymes up

General Information

General Information Comment Organism
metabolism transcriptional induction of the enzyme causes changes in expression levels of other mitochondrial enzymes. Activities of the protein complexes of the respiratory chain were not significantly altered. But activity of glutamate dehydrogenase substantially increased, indicating upregulation of the entire proline catabolic pathway. Induction of D-lactate dehydrogenase activity allows rapid upregulation of ProDH activity during the short-term stress response in plants Arabidopsis thaliana
physiological function transcriptional induction of the enzyme causes changes in expression levels of other mitochondrial enzymes. Activity of glutamate dehydrogenase substantially increased, indicating upregulation of the entire proline catabolic pathway Arabidopsis thaliana