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Literature summary for 1.5.3.6 extracted from

  • Stoltz, M.; Rysavy, P.; Kalousek, F.; Brandsch, R.
    Folding, flavinylation, and mitochondrial import of 6-hydroxy-D-nicotine oxidase fused to the presequence of rat dimethylglycine dehydrogenase (1995), J. Biol. Chem., 270, 8016-8022.
    View publication on PubMed
Search for more literature for 1.5.3.6

Activating Compound

Activating Compound Comment Organism Structure
glycerol-3-phosphate activation of autocatalytical flavinylation of the enzyme in rabbit reticulocyte lysate Paenarthrobacter nicotinovorans

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 as a fusion protein with dimethylglycine dehydrogenase and translated into rabbit reticulocyte lysate Paenarthrobacter nicotinovorans

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-6-hydroxynicotine + H2O + O2 Paenarthrobacter nicotinovorans
-
 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Paenarthrobacter nicotinovorans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-6-hydroxynicotine + H2O + O2
-
 Paenarthrobacter nicotinovorans 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD formation of the bond to FAD proceeds autocatalytically Paenarthrobacter nicotinovorans
FAD covalently bound to a histidine Paenarthrobacter nicotinovorans