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Literature summary for 1.5.3.16 extracted from

  • Vujcic, S.; Diegelman, P.; Bacchi, C.J.; Kramer, D.L.; Porter, C.W.
    Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin (2002), Biochem. J., 367, 665-675.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
cDNA is transiently transfected into HEK-293 cells Mus musculus
cDNA is transiently transfected into HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
MDL-72527 0.2 mM, 41% inhibition Homo sapiens
N1,N11-diethylnorspermine 0.2 mM, 21% inhibition Homo sapiens
N1,N12-diethylspermine 0.2 mM, 15% inhibition Homo sapiens
N1,N14-diethylhomospermine 0.2 mM, 49% inhibition Homo sapiens
N1-(n-octanesulfonyl)spermine 0.2 mM, 86% inhibition Homo sapiens
spermidine 0.2 mM, 41% inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
spermine + O2 + H2O Homo sapiens SMO may contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-aminopropanal spermidine + 3-aminopropanal + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NWM0
-
-
Mus musculus Q99K82
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with: spermidine, N1,N12-diacetylspermine, N1,N12-diethylspermine, N1,N14-diethylhomospermine, MDL-72527, N1,N11-diethylnorspermine Homo sapiens ?
-
?
N1-acetylspermine + O2 + H2O very poor substrate Homo sapiens ?
-
?
N1-monoethylspermine + O2 + H2O 98% of the activity with spermine Homo sapiens spermidine + ?
-
?
spermine + O2 + H2O
-
Homo sapiens spermidine + 3-aminopropanal + H2O2
-
?
spermine + O2 + H2O SMO may contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-aminopropanal Homo sapiens spermidine + 3-aminopropanal + H2O2
-
?
spermine + O2 + H2O strongly favours spermine over N1-acetylspermine, fails to act on N1-acetylspermidine, spermidine or the preferred PAO substrate, N1,N12-diacetylspermine Mus musculus spermidine + 3-aminopropanal + H2O2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
FAD
-
Homo sapiens