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Literature summary for 1.5.1.7 extracted from

  • Xu, H.; West, A.H.; Cook, P.F.
    Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae (2007), Biochemistry, 46, 7625-7636.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2',3'-cyclic NADP
-
Saccharomyces cerevisiae
2',3'-cyclic NADP+
-
Saccharomyces cerevisiae
adenosine
-
Saccharomyces cerevisiae
adipate
-
Saccharomyces cerevisiae
ADP
-
Saccharomyces cerevisiae
ADP-ribose
-
Saccharomyces cerevisiae
alpha-ketoadipate
-
Saccharomyces cerevisiae
alpha-ketoglutarate
-
Saccharomyces cerevisiae
alpha-ketoisovalerate
-
Saccharomyces cerevisiae
alpha-ketomalonate
-
Saccharomyces cerevisiae
alpha-ketopimelate
-
Saccharomyces cerevisiae
AMP
-
Saccharomyces cerevisiae
D-Lysine
-
Saccharomyces cerevisiae
Glutarate
-
Saccharomyces cerevisiae
L-arginine
-
Saccharomyces cerevisiae
L-glutamine
-
Saccharomyces cerevisiae
L-isoleucine
-
Saccharomyces cerevisiae
L-leucine dead-end inhibition by L-leucine is uncompetitive versus NADPH Saccharomyces cerevisiae
L-lysine
-
Saccharomyces cerevisiae
L-methionine
-
Saccharomyces cerevisiae
L-norvaline
-
Saccharomyces cerevisiae
L-ornithine
-
Saccharomyces cerevisiae
L-valine
-
Saccharomyces cerevisiae
malonate
-
Saccharomyces cerevisiae
additional information not inhibited by L-asparagine at pH 7.0 Saccharomyces cerevisiae
NAD+
-
Saccharomyces cerevisiae
NADH
-
Saccharomyces cerevisiae
NADP+ NADP+ is competitive versus NADPH when NADPH serves as the coenzyme Saccharomyces cerevisiae
NMN
-
Saccharomyces cerevisiae
oxalate
-
Saccharomyces cerevisiae
oxaloacetate
-
Saccharomyces cerevisiae
oxalylglycine
-
Saccharomyces cerevisiae
pyridine 2,3-dicarboxylate
-
Saccharomyces cerevisiae
Pyridine 2,4-dicarboxylate
-
Saccharomyces cerevisiae
succinate
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
2-oxoglutarate at pH 7.0 Saccharomyces cerevisiae
4.1
-
pyruvate at pH 7.0 Saccharomyces cerevisiae
5.3
-
alpha-ketoadipate at pH 7.0 Saccharomyces cerevisiae
6.4
-
glyoxylate at pH 7.0 Saccharomyces cerevisiae
24
-
alpha-ketomalonate at pH 7.0 Saccharomyces cerevisiae
94
-
alpha-ketovalerate at pH 7.0 Saccharomyces cerevisiae
153
-
alpha-Ketobutyrate at pH 7.0 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + alpha-ketoadipate + NADH
-
Saccharomyces cerevisiae ?
-
?
L-lysine + alpha-ketobutyrate + NADH
-
Saccharomyces cerevisiae ?
-
?
L-lysine + alpha-ketomalonate + NADH
-
Saccharomyces cerevisiae ?
-
?
L-lysine + alpha-ketovalerate + NADH
-
Saccharomyces cerevisiae ?
-
?
L-lysine + glyoxylate + NADH
-
Saccharomyces cerevisiae ?
-
?
L-lysine + pyruvate + NADH
-
Saccharomyces cerevisiae ?
-
?
additional information 3-acetylpyridine adenine dinucleotide, 3-pyridinealdehyde adenine dinucleotide, and thionicotinamide adenine dinucleotide can serve as a substrate in the oxidative deamination reaction, as can glyoxylate, pyruvate, alpha-ketobutyrate, alpha-ketovalerate, alpha-ketomalonate, and alpha-ketoadipate in the reverse reaction Saccharomyces cerevisiae ?
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O the enzyme is specific for L-lysine Saccharomyces cerevisiae L-lysine + 2-oxoglutarate + NADH + H+
-
r

Synonyms

Synonyms Comment Organism
N6-(glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)
-
Saccharomyces cerevisiae
SDH
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Saccharomyces cerevisiae
NADH
-
Saccharomyces cerevisiae
NADPH NADPH can substitute for NADH Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.018
-
NADH at pH 7.0 Saccharomyces cerevisiae
0.055
-
AMP at pH 7.0 Saccharomyces cerevisiae
0.093
-
ADP at pH 7.0 Saccharomyces cerevisiae
0.1
-
oxalylglycine at pH 7.0 Saccharomyces cerevisiae
0.125
-
L-leucine at pH 6.0 Saccharomyces cerevisiae
0.29
-
ADP-ribose at pH 7.0 Saccharomyces cerevisiae
0.42
-
adenosine at pH 7.0 Saccharomyces cerevisiae
0.6
-
alpha-ketoglutarate at pH 7.0 Saccharomyces cerevisiae
1
-
Glutarate at pH 7.0 Saccharomyces cerevisiae
1.1
-
L-lysine at pH 7.0 Saccharomyces cerevisiae
1.1
-
Pyridine 2,4-dicarboxylate at pH 7.0 Saccharomyces cerevisiae
1.13
-
L-norvaline at pH 7.0 Saccharomyces cerevisiae
1.2
-
NADP at pH 7.0 Saccharomyces cerevisiae
1.5
-
2',3'-cyclic NADP at pH 7.0 Saccharomyces cerevisiae
1.56
-
NAD+ at pH 7.0 Saccharomyces cerevisiae
3.12
-
L-methionine at pH 7.0 Saccharomyces cerevisiae
3.5
-
NADP+ at pH 7.0 Saccharomyces cerevisiae
5
-
L-ornithine at pH 7.0 Saccharomyces cerevisiae
5.3
-
alpha-ketoadipate at pH 7.0 Saccharomyces cerevisiae
5.5
-
D-Lysine at pH 7.0 Saccharomyces cerevisiae
5.6
-
L-leucine at pH 7.0 Saccharomyces cerevisiae
6.4
-
oxaloacetate at pH 7.0 Saccharomyces cerevisiae
7.2
-
NMN at pH 7.0 Saccharomyces cerevisiae
16
-
L-glutamine at pH 7.0 Saccharomyces cerevisiae
16.4
-
L-arginine at pH 7.0 Saccharomyces cerevisiae
18
-
alpha-ketopimelate at pH 7.0 Saccharomyces cerevisiae
18.3
-
pyridine 2,3-dicarboxylate at pH 7.0 Saccharomyces cerevisiae
21
-
succinate at pH 7.0 Saccharomyces cerevisiae
22
-
L-isoleucine at pH 7.0 Saccharomyces cerevisiae
24
-
malonate at pH 7.0 Saccharomyces cerevisiae
24
-
alpha-ketomalonate at pH 7.0 Saccharomyces cerevisiae
36
-
oxalate at pH 7.0 Saccharomyces cerevisiae
36
-
alpha-ketoisovalerate at pH 7.0 Saccharomyces cerevisiae
50
-
adipate at pH 7.0 Saccharomyces cerevisiae
140
-
L-valine at pH 7.0 Saccharomyces cerevisiae