BRENDA - Enzyme Database
show all sequences of 1.5.1.6

Isolation and characterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase

Hong, M.; Lee, Y.; Kim, J.W.; Lim, J.S.; Chang, S.Y.; Lee, K.S.; Paik, S.G.; Choe, I.S.; Biochem. Mol. Biol. Int. 47, 407-415 (1999)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels
Homo sapiens
Cloned(Commentary)
Commentary
Organism
cloning and sequencing of the cDNA encoding FDH from fetal liver
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
98700
-
x * 98700, protein with 902 amino acids, calculated from cDNA
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
10-formyltetrahydrofolate + NADP+ + H2O
Homo sapiens
enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning
tetrahydrofolate + CO2 + NADPH + H+
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
additional information
protein with conserved potential N-glycosylation sites, protein kinase phosphorylation sites, and N-myristoylation sites, post-translational modification may be important for the function
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
mainly expressed in
Homo sapiens
-
liver
mainly expressed in fetal liver
Homo sapiens
-
muscle
mainly expressed in skeletal muscle
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
10-formyltetrahydrofolate + NADP+ + H2O
Cys-707 is involved in enzyme activity
392348
Homo sapiens
tetrahydrofolate + CO2 + NADPH + H+
-
392348
Homo sapiens
?
10-formyltetrahydrofolate + NADP+ + H2O
enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning
392348
Homo sapiens
tetrahydrofolate + CO2 + NADPH + H+
-
392348
Homo sapiens
?
Subunits
Subunits
Commentary
Organism
?
x * 98700, protein with 902 amino acids, calculated from cDNA
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
10-formyltetrahydrofolate
10-formyltetrahydrofolate
Homo sapiens
NADP+
-
Homo sapiens
tetrahydrofolate
-
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
cloning and sequencing of the cDNA encoding FDH from fetal liver
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
10-formyltetrahydrofolate
10-formyltetrahydrofolate
Homo sapiens
NADP+
-
Homo sapiens
tetrahydrofolate
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
98700
-
x * 98700, protein with 902 amino acids, calculated from cDNA
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
10-formyltetrahydrofolate + NADP+ + H2O
Homo sapiens
enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning
tetrahydrofolate + CO2 + NADPH + H+
-
Homo sapiens
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
additional information
protein with conserved potential N-glycosylation sites, protein kinase phosphorylation sites, and N-myristoylation sites, post-translational modification may be important for the function
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
mainly expressed in
Homo sapiens
-
liver
mainly expressed in fetal liver
Homo sapiens
-
muscle
mainly expressed in skeletal muscle
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
10-formyltetrahydrofolate + NADP+ + H2O
Cys-707 is involved in enzyme activity
392348
Homo sapiens
tetrahydrofolate + CO2 + NADPH + H+
-
392348
Homo sapiens
?
10-formyltetrahydrofolate + NADP+ + H2O
enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning
392348
Homo sapiens
tetrahydrofolate + CO2 + NADPH + H+
-
392348
Homo sapiens
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 98700, protein with 902 amino acids, calculated from cDNA
Homo sapiens
Other publictions for EC 1.5.1.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742257
Tsybovsky
The mechanism of discriminati ...
Rattus norvegicus
Chem. Biol. Interact.
202
62-69
2013
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1
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1
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724712
Strickland
Enzymatic properties of ALDH1L ...
Homo sapiens
Chem. Biol. Interact.
191
129-136
2011
1
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1
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3
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1
1
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1
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712429
Strickland
Acyl carrier protein-specific ...
Homo sapiens
J. Biol. Chem.
285
1627-1633
2010
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1
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3
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712450
Krupenko
ALDH1L2 is the mitochondrial h ...
Homo sapiens
J. Biol. Chem.
285
23056-23063
2010
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1
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2
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1
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4
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1
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6
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1
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2
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1
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9
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1
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713460
Chang
Zebrafish 10-formyltetrahydrof ...
Danio rerio
Protein Expr. Purif.
72
217-222
2010
-
-
1
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2
-
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2
-
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4
-
-
1
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1
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1
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1
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1
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2
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2
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1
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1
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2
1
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1
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713003
Ghose
10-formyltetrahydrofolate dehy ...
Homo sapiens
Mol. Cancer Res.
7
99-107
2009
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1
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2
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1
1
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-
697029
McNeil
Disruption of lipid metabolism ...
Rattus norvegicus
Br. J. Nutr.
99
262-271
2008
-
-
-
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2
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1
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1
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2
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1
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1
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2
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674389
Kim
Rat liver 10-formyltetrahydrof ...
Rattus norvegicus
J. Biochem. Mol. Biol.
40
604-609
2007
-
-
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1
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3
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2
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685138
Tsybovsky
Crystal structures of the carb ...
Rattus norvegicus
Biochemistry
46
2917-2929
2007
-
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1
1
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2
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1
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1
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1
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1
1
1
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1
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1
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687640
Donato
10-formyltetrahydrofolate dehy ...
Rattus norvegicus
J. Biol. Chem.
282
34159-34166
2007
-
-
1
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1
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2
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1
1
1
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1
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1
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671194
Min
Effects of chronic ethanol ing ...
Rattus norvegicus
Alcohol. Clin. Exp. Res.
29
2188-2193
2005
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1
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2
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2
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2
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671840
Oleinik
Cancer cells activate p53 in r ...
Homo sapiens
Biochem. J.
391
503-511
2005
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1
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1
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2
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1
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1
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652526
Chumanevich
The crystal structure of the h ...
Rattus norvegicus
J. Biol. Chem.
279
14355-14364
2004
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1
5
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2
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656137
Reuland
Disruption of a calmodulin cen ...
Rattus norvegicus
J. Biol. Chem.
278
22894-22900
2003
-
-
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9
-
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2
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1
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2
1
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9
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2
1
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656770
Oleinik
Ectopic expression of 10-formy ...
Homo sapiens
Mol. Cancer Res.
1
577-588
2003
-
-
-
-
-
-
-
-
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-
1
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1
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1
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1
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1
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2
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392350
Krupenko
10-Formyltetrahydrofolate dehy ...
Homo sapiens, Rattus norvegicus
Cell Growth Differ.
13
227-236
2002
-
-
2
-
2
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-
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2
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3
-
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22
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3
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6
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2
6
-
2
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2
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22
-
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3
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392346
Krupenko
On the role of conserved histi ...
Rattus norvegicus
J. Biol. Chem.
276
24030-24037
2001
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1
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2
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1
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1
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2
1
1
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392345
Krupenko
Aspartate 142 is involved in b ...
Rattus norvegicus
J. Biol. Chem.
274
35777-35784
1999
-
-
1
-
1
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1
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1
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1
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1
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1
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5
1
1
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3
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1
3
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1
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1
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1
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1
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1
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5
1
1
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392348
Hong
Isolation and characterization ...
Homo sapiens
Biochem. Mol. Biol. Int.
47
407-415
1999
-
1
1
-
-
-
-
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1
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1
1
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3
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1
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5
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2
1
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3
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1
1
3
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1
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1
1
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1
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5
-
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2
1
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-
392347
Krupenko
Overexpression of functional h ...
Rattus norvegicus
Protein Expr. Purif.
14
146-152
1998
-
-
1
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1
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1
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4
-
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1
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3
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2
1
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3
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1
3
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1
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1
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1
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3
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2
1
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392352
Kim
Identification of protein-argi ...
Rattus norvegicus
J. Biol. Chem.
273
27374-27382
1998
1
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1
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1
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1
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2
1
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2
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1
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1
1
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5
1
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4
-
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1
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1
4
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1
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