Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ | Agrobacterium tumefaciens | - |
carboxynorspermidine + H2O + NADP+ | ? | ? | |
L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ | Agrobacterium tumefaciens C58 / ATCC 33970 | - |
carboxynorspermidine + H2O + NADP+ | ? | ? | |
L-aspartate 4-semialdehyde + putrescine + NADPH + H+ | Agrobacterium tumefaciens | - |
carboxyspermidine + H2O + NADP+ | ? | ? | |
L-aspartate 4-semialdehyde + putrescine + NADPH + H+ | Agrobacterium tumefaciens C58 / ATCC 33970 | - |
carboxyspermidine + H2O + NADP+ | ? | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium tumefaciens | A9CG66 | - |
- |
Agrobacterium tumefaciens C58 / ATCC 33970 | A9CG66 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ | - |
Agrobacterium tumefaciens | carboxynorspermidine + H2O + NADP+ | ? | ? | |
L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ | - |
Agrobacterium tumefaciens C58 / ATCC 33970 | carboxynorspermidine + H2O + NADP+ | ? | ? | |
L-aspartate 4-semialdehyde + putrescine + NADPH + H+ | - |
Agrobacterium tumefaciens | carboxyspermidine + H2O + NADP+ | ? | ? | |
L-aspartate 4-semialdehyde + putrescine + NADPH + H+ | - |
Agrobacterium tumefaciens C58 / ATCC 33970 | carboxyspermidine + H2O + NADP+ | ? | ? |
Synonyms | Comment | Organism |
---|---|---|
Atu4170 | - |
Agrobacterium tumefaciens |
carboxyspermidine dehydrogenase | - |
Agrobacterium tumefaciens |
CASDH | - |
Agrobacterium tumefaciens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Agrobacterium tumefaciens |
General Information | Comment | Organism |
---|---|---|
malfunction | the DELTACASDH (Atu4170) mutant strain accumulates putrescine and homospermidine but lacks spermidine. The DELTA4170 strain contains endogenously produced putrescine and homospermidine, but there is no growth of this strain in the absence of exogenously supplied polyamines. Homospermidine biosynthesis is induced only after spermidine depletion. The DELTACASDH strain grows well in medium with added exogenous N8-acetylspermidine | Agrobacterium tumefaciens |
metabolism | when spermidine levels are pharmacologically decreased, synthesis of spermine from spermidine is induced via the same biosynthetic enzymes, carboxyspermidine dehydrogenase and carboxyspermidine decarboxylase that produce spermidine from putrescine. Spermidine represses spermine biosynthesis, but when spermidine levels decrease, it is then converted by carboxyspermidine dehydrogenase and decarboxylase enzymes to spermine, which is resistant to retroconversion and constitutes a sequestered pool of protected 1,3-diaminopropane modules required for growth. Polyamine biosynthesis in Agrobacterium tumefaciens strain C58, overview | Agrobacterium tumefaciens |
physiological function | when spermidine levels are pharmacologically decreased, synthesis of spermine from spermidine is induced via the same biosynthetic enzymes, carboxyspermidine dehydrogenase and carboxyspermidine decarboxylase that produce spermidine from putrescine. Essential role of a terminal 1,3-diaminopropane moiety in growth of Agrobacterium tumefaciens | Agrobacterium tumefaciens |