Literature summary for 1.5.1.34 extracted from

Lee, C.K.; Han, J.S.; Won, K.J.; Jung, S.H.; Park, H.J.; Lee, H.M.; Kim, J.; Park, Y.S.; Kim, H.J.; Park, P.J.; Park, T.K.; Kim, B.
Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels (2009), Proteomics, 9, 4851-4858.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dihydrobiopterin + NADH + H+	Rattus norvegicus	pH 7.4, 37°C	tetrahydrobiopterin + NAD+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	spontaneously hypertensive rats of various ages and age-matched normotensive Wistar-Kyoto rats	-

Purification (Commentary)

Purification (Comment)	Organism
homogenization of smooth muscle strips in 2-DE lysis buffer containing 8 M urea, 2 M thiourea, 65 mM DTT, 2% CHAPS, and protease inhibitor cocktail, centrifugation, supernatant used for 2-DE and MALDI-TOF/TOF-MS	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
aortic smooth muscle	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	dihydropteridine reductase activity is reduced in 5-week-old (-11.8fold), 8-week-old (-18.4fold), and 13-week-old (-37.4fold) hypertensive rats compared to normotensive rats	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydrobiopterin + NADH + H+	pH 7.4, 37°C	Rattus norvegicus	tetrahydrobiopterin + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
DHPR	-	Rattus norvegicus
dihydropteridine reductase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	enzyme in the regeneration pathway of tetrahydrobiopterin, expression is reduced in hypertensive rats compared to normotensive rats, tetrahydrobiopterin levels are attenuated in hypertensive rat aortic smooth muscle, tetrahydrobiopterin inhibits a serotonin-mediated vascular contraction increase	Rattus norvegicus

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Release 2023.1 (January 2023)