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Literature summary for 1.5.1.34 extracted from

  • Concolino, D.; Muzzi, G.; Rapsomaniki, M.; Moricca, M.T.; Pascale, M.G.; Strisciuglio, P.
    Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients (2008), J. Inherit. Metab. Dis., Suppl. 2, 193-197.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens essential part of the hydroxylating system of the aromatic amino acids phenylalanine, tyrosine and tryptophan, reduces quinonoid dihydropterine to regenerate tetrahydrobiopterin, main metabolic derangements caused by DHPR deficiency are hyperphenylalaninaemia and impaired production of the monoamine neurotransmitters dopamine, noradrenaline and serotonin, DHPR deficiency patients can develop severe and progressive neurological damage ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients from Calabria, Italy, one patient with traces of activity, two patients without activity
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information essential part of the hydroxylating system of the aromatic amino acids phenylalanine, tyrosine and tryptophan, reduces quinonoid dihydropterine to regenerate tetrahydrobiopterin, main metabolic derangements caused by DHPR deficiency are hyperphenylalaninaemia and impaired production of the monoamine neurotransmitters dopamine, noradrenaline and serotonin, DHPR deficiency patients can develop severe and progressive neurological damage Homo sapiens ?
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?

Subunits

Subunits Comment Organism
dimer homodimer Homo sapiens

Synonyms

Synonyms Comment Organism
DHPR
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Homo sapiens
DQPR gene product
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Homo sapiens
EC 1.6.99.7 formerly Homo sapiens