Literature summary for 1.5.1.34 extracted from

Varughese, K.I.; Xuong, N.H.; Kiefer, P.M.; Matthews, D.A.; Whiteley, J.M.
Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases (1994), Proc. Natl. Acad. Sci. USA, 91, 5582-5586.

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Protein Variants

Protein Variants	Comment	Organism
Y146F	2 orders of magnitude lower kcat than the wild-type enzyme	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+	structural and mechanistic characteristics	Rattus norvegicus	a

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Release 2023.1 (January 2023)