Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.34 extracted from

  • Abell, C.W.; Shen, R.S.; Gessner, W.; Brossi, A.
    Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs (1984), Science, 224, 405-407.
    View publication on PubMed
Search for more literature for 1.5.1.34

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0034 mM, 50% inhibition Homo sapiens
1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
1-methyl-4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0093 mM, 50% inhibition Homo sapiens
1-methyl-4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
1-methyl-4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine 0.27 mM, 50% inhibition Homo sapiens
1-methyl-4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.003 mM, 50% inhibition Homo sapiens
1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 0.3 mM, 50% inhibition Homo sapiens
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0036 mM, 50% inhibition Homo sapiens
4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0072 mM, 50% inhibition Homo sapiens
4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine 0.34 mM, 50% inhibition Homo sapiens
4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0059 mM, 50% inhibition Homo sapiens
4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus
4-phenyl-1,2,3,6-tetrahydropyridine 12 mM, 50% inhibition Homo sapiens
4-phenyl-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
synaptosome striatum Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0028
-
 1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine noncompetitive inhibition Homo sapiens