Literature summary for 1.5.1.34 extracted from

Shen, R.S.
Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver (1984), Biochim. Biophys. Acta, 785, 181-185.

Search for more literature for 1.5.1.34

Inhibitors

Inhibitors	Comment	Organism	Structure
3(4-hydroxyphenyl)pyruvate	0.0033 mM, 50% inhibition	Homo sapiens
3(4-hydroxyphenyl)pyruvate	0.0044 mM, 50% inhibition	Ovis aries
3-phenylpyruvic acid	4.7 mM, 50% inhibition	Homo sapiens
3-phenylpyruvic acid	5.9 mM, 50% inhibition	Ovis aries
4-hydroxyphenyllactate	0.058 mM, 50% inhibition	Homo sapiens
4-hydroxyphenyllactate	0.071 mM, 50% inhibition	Ovis aries
L-beta-3,4-dihydroxyphenylalanine	0.23 mM, 50% inhibition	Homo sapiens
L-beta-3,4-dihydroxyphenylalanine	trivial name L-DOPA, 0.34 mM, 50% inhibition	Ovis aries
L-tyrosine	0.44 mM, 50% inhibition	Homo sapiens
L-tyrosine	0.61 mM, 50% inhibition	Ovis aries
m-tyramine	0.036 mM, 50% inhibition	Homo sapiens
m-tyramine	0.044 mM, 50% inhibition	Ovis aries
o-hydroxyphenylacetic acid	6.9 mM, 50% inhibition	Homo sapiens
o-hydroxyphenylacetic acid	8.1 mM, 50% inhibition	Ovis aries
phenylacetic acid	6.6 mM, 50% inhibition	Homo sapiens
phenylacetic acid	6.9 mM, 50% inhibition	Ovis aries
tyramine	0.04 mM, 50% inhibition	Homo sapiens
tyramine	0.046 mM, 50% inhibition	Ovis aries
[4-hydroxyphenyl]acetic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Ovis aries	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-
liver	-	Rattus norvegicus	-
liver	-	Ovis aries	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0037	-	3-(4-hydroxyphenyl)pyruvate	-	Homo sapiens
0.05	-	tyramine	-	Homo sapiens
0.067	-	m-tyramine	-	Homo sapiens
0.074	-	[4-hydroxyphenyl]acetic acid	-	Homo sapiens
0.25	-	L-tyrosine	-	Homo sapiens
0.26	-	L-Dopa	-	Homo sapiens

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Release 2023.1 (January 2023)