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Literature summary for 1.5.1.34 extracted from

  • Firgaira, F.A.; Cotton, R.G.H.; Jennings, I.; Danks, D.M.
    Use of naphthoquinone adsorbent for the isolation of human dihydropteridine reductase (1987), Methods Enzymol., 142, 116-126.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
 5,6,7,8-tetrahydrobiopterin 37°C, pH 7.2 Homo sapiens
0.029
-
 NADPH 37°C, pH 7.2 Homo sapiens
0.036
-
 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydro-pteridine 37°C, pH 7.2 Homo sapiens
0.77
-
 NADH 37°C, pH 7.2 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 2 * 26000, SDS-PAGE Homo sapiens
47500
-
 gel filtration Homo sapiens
50000
-
 sedimentation equilibrium Homo sapiens
54000
-
 gradient PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H Homo sapiens essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
422
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
-
 Homo sapiens 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
 ?
6,7-dihydropteridine + NADH
-
 Homo sapiens (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
 ?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan Homo sapiens 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 26000, SDS-PAGE Homo sapiens