Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-(1-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]ethyl)phenyl)methanol | - |
Escherichia coli | |
(4-(1-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]ethyl)phenyl)methanol | - |
Homo sapiens | |
1-(3-([(2,4-diaminopteridin-6-yl)methyl]amino)phenyl)ethanol | - |
Escherichia coli | |
1-(3-([(2,4-diaminopteridin-6-yl)methyl]amino)phenyl)ethanol | - |
Homo sapiens | |
2-(2-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)ethoxy)ethanol | - |
Escherichia coli | |
2-(2-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)ethoxy)ethanol | - |
Homo sapiens | |
2-(2-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)[1-(naphthalen-1-yl)ethyl]amino)ethoxy)ethanol | - |
Escherichia coli | |
2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]ethanol | - |
Escherichia coli | |
2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]ethanol | - |
Homo sapiens | |
2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]-2-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethanol | - |
Escherichia coli | |
2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]-2-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethanol | - |
Homo sapiens | |
3-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)propanoic acid | - |
Escherichia coli | |
3-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)[1-(naphthalen-1-yl)ethyl]amino)propanoic acid | - |
Escherichia coli | |
4-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)butanoic acid | - |
Escherichia coli | |
4-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)butanoic acid | - |
Homo sapiens | |
4-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)[1-(naphthalen-1-yl)ethyl]amino)butanoic acid | - |
Escherichia coli | |
4-([(2,4-diaminopteridin-6-yl)methyl](methyl)amino)benzoic acid | - |
Escherichia coli | |
4-([(2,4-diaminopteridin-6-yl)methyl](methyl)amino)benzoic acid | - |
Homo sapiens | |
6-(([4-chlorotricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]amino)methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-(([4-chlorotricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]amino)methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([(3-nitrophenyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([(3-nitrophenyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([(4-aminophenyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([(4-aminophenyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([(4-ethoxyphenyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([(4-ethoxyphenyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([5-quinolylamino]-methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine | enzyme-bound crystal structure analysis for inhibitor screening and docking studies, PDB ID 1KMS | Homo sapiens | |
6-([butyl(phenyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([butyl(phenyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([ethyl(phenyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([ethyl(phenyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([methyl(3-nitrophenyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([methyl(3-nitrophenyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([methyl(phenyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([methyl(phenyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([phenyl(prop-2-en-1-yl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([phenyl(prop-2-en-1-yl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([phenyl(propan-2-yl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([phenyl(propan-2-yl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([phenyl(propyl)amino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([phenyl(propyl)amino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylamino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylamino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-ylamino]methyl)pteridine-2,4-diamine | - |
Escherichia coli | |
6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-ylamino]methyl)pteridine-2,4-diamine | - |
Homo sapiens | |
6-[(phenylamino)methyl]pteridine-2,4-diamine | - |
Escherichia coli | |
6-[(phenylamino)methyl]pteridine-2,4-diamine | - |
Homo sapiens | |
6-[(tricyclo[4.3.0.07,9]nona-1,3,5-trien-3-ylamino)methyl]pteridine-2,4-diamine | - |
Escherichia coli | |
6-[(tricyclo[4.3.0.07,9]nona-1,3,5-trien-3-ylamino)methyl]pteridine-2,4-diamine | - |
Homo sapiens | |
methotrexate | enzyme-bound crystal structure analysis for inhibitor screening and docking studies, PDB ID 1RA3 | Escherichia coli | |
methotrexate | - |
Homo sapiens | |
methyl 4-([(2,4-diaminopteridin-6-yl)methyl](methyl)amino)benzoate | - |
Escherichia coli | |
methyl 4-([(2,4-diaminopteridin-6-yl)methyl](methyl)amino)benzoate | - |
Homo sapiens | |
additional information | inhibitory potencies of diverse 2,4-pteridinediamine derivates and pyrimido[4,5-d]pyrimidine-2,4-diamine derivates, molecular dynamic simulations, detailed overview | Escherichia coli | |
additional information | inhibitory potencies of diverse 2,4-pteridinediamine derivates and pyrimido[4,5-d]pyrimidine-2,4-diamine derivates, molecular dynamic simulations, detailed overview | Homo sapiens | |
N-(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)-N-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)-beta-alanine | - |
Homo sapiens | |
N-(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)-N-[1-(2-ethoxynaphthalen-1-yl)ethyl]-b-alanine | - |
Escherichia coli | |
N-(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)-N-[1-(2-ethoxynaphthalen-1-yl)ethyl]-b-alanine | - |
Homo sapiens | |
N7-(1-(naphthalen-1-yl)ethyl)-N7-propylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(1-(naphthalen-1-yl)ethyl)-N7-propylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(2-aminoethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(2-aminoethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(2-aminoethyl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(2-ethoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(2-ethoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(2-ethoxyethyl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(2-propoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(2-propoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(2-propoxyethyl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(3-ethoxypropyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(3-ethoxypropyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(3-ethoxypropyl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(4-aminobutyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(4-aminobutyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(4-aminobutyl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(5-aminopentyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(5-aminopentyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(5-aminopentyl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(cyclopropylmethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(cyclopropylmethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(cyclopropylmethyl)-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(cyclopropylmethyl)-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(cyclopropylmethyl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(prop-2-en-1-yl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-(prop-2-en-1-yl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-(prop-2-en-1-yl)-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-benzyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-benzyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-benzyl-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-benzyl-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-benzyl-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-butyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-butyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-butyl-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-cyclopropyl-N7-(1-(naphthalen-2-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-cyclopropyl-N7-(1-(naphthalen-2-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-cyclopropyl-N7-[1-(naphthalen-2-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-ethyl-N7-(4-methylbenzyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-ethyl-N7-(4-methylbenzyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-ethyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-ethyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-methyl-N7-(1-phenylethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-methyl-N7-(1-phenylethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-methyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-methyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-methyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-methyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-methyl-N7-[1-(quinolin-4-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-methyl-N7-[1-(quinolin-4-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-methyl-N7-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylmethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-methyl-N7-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylmethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-pentyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-pentyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-pentyl-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-ethylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-ethylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[1-(2-ethoxynaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[1-(2-ethoxynaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[1-(2-ethylnaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[1-(2-ethylnaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[1-(4-chloronaphthalen-1-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[1-(4-chloronaphthalen-1-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[1-(naphthalen-1-yl)ethyl]-N7-propylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[2-(4-fluorophenyl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[2-(4-fluorophenyl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[2-(4-fluorophenyl)ethyl]-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[2-(cyclohex-2-en-1-yl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[2-(cyclohex-2-en-1-yl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[2-(cyclohex-2-en-1-yl)ethyl]-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[3-(2-methyl-4H-imidazol-4-yl)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[3-(2-methyl-4H-imidazol-4-yl)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[3-(2-methyl-4H-imidazol-4-yl)propyl]-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[3-(2-methylpropoxy)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
N7-[3-(2-methylpropoxy)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Homo sapiens | |
N7-[3-(2-methylpropoxy)propyl]-N7-[1-(naphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | - |
Escherichia coli | |
trimethoprim | - |
Escherichia coli | |
trimethoprim | - |
Homo sapiens | |
[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]acetic acid | - |
Escherichia coli | |
[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]acetic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | Homo sapiens | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | Escherichia coli | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0ABQ4 | - |
- |
Homo sapiens | P00374 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | - |
Homo sapiens | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | - |
Escherichia coli | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
dihydrofolate + NADPH + H+ | - |
Homo sapiens | tetrahydrofolate + NADP+ | - |
? | |
dihydrofolate + NADPH + H+ | - |
Escherichia coli | tetrahydrofolate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHFR | - |
Homo sapiens |
DHFR | - |
Escherichia coli |
dihydrofolate reductase | - |
Homo sapiens |
dihydrofolate reductase | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
7 | - |
assay at | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000016 | - |
pH 7.0, 37°C | Escherichia coli | N7-methyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00005 | - |
pH 7.0, 37°C | Escherichia coli | N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.000055 | - |
pH 7.0, 37°C | Escherichia coli | N7-methyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00011 | - |
pH 7.0, 37°C | Escherichia coli | 6-([ethyl(phenyl)amino]methyl)pteridine-2,4-diamine | |
0.00015 | - |
pH 7.0, 37°C | Escherichia coli | 6-([phenyl(propyl)amino]methyl)pteridine-2,4-diamine | |
0.00015 | - |
pH 7.0, 37°C | Escherichia coli | 6-([phenyl(prop-2-en-1-yl)amino]methyl)pteridine-2,4-diamine | |
0.00015 | - |
pH 7.0, 37°C | Escherichia coli | N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-ethylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0002 | - |
pH 7.0, 37°C | Escherichia coli | N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0002 | - |
pH 7.0, 37°C | Escherichia coli | 4-([(2,4-diaminopteridin-6-yl)methyl](methyl)amino)benzoic acid | |
0.00021 | - |
pH 7.0, 37°C | Escherichia coli | N7-ethyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00027 | - |
pH 7.0, 37°C | Escherichia coli | N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0003 | - |
pH 7.0, 37°C | Homo sapiens | methyl 4-([(2,4-diaminopteridin-6-yl)methyl](methyl)amino)benzoate | |
0.0003 | - |
pH 7.0, 37°C | Escherichia coli | 2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]ethanol | |
0.0004 | - |
pH 7.0, 37°C | Escherichia coli | N7-(prop-2-en-1-yl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0005 | - |
pH 7.0, 37°C | Homo sapiens | 6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylamino]methyl)pteridine-2,4-diamine | |
0.0005 | - |
pH 7.0, 37°C | Homo sapiens | 6-(([4-chlorotricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]amino)methyl)pteridine-2,4-diamine | |
0.0006 | - |
pH 7.0, 37°C | Escherichia coli | 6-([butyl(phenyl)amino]methyl)pteridine-2,4-diamine | |
0.0006 | - |
pH 7.0, 37°C | Escherichia coli | 6-(([4-chlorotricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]amino)methyl)pteridine-2,4-diamine | |
0.0006 | - |
pH 7.0, 37°C | Escherichia coli | N7-(cyclopropylmethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0007 | - |
pH 7.0, 37°C | Escherichia coli | N7-methyl-N7-[1-(quinolin-4-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0008 | - |
pH 7.0, 37°C | Escherichia coli | N7-[3-(2-methyl-4H-imidazol-4-yl)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00085 | - |
pH 7.0, 37°C | Homo sapiens | N7-methyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00088 | - |
pH 7.0, 37°C | Homo sapiens | 6-([phenyl(propan-2-yl)amino]methyl)pteridine-2,4-diamine | |
0.00088 | - |
pH 7.0, 37°C | Escherichia coli | 6-([phenyl(propan-2-yl)amino]methyl)pteridine-2,4-diamine | |
0.00088 | - |
pH 7.0, 37°C | Escherichia coli | N7-benzyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00093 | - |
pH 7.0, 37°C | Escherichia coli | 3-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)propanoic acid | |
0.00096 | - |
pH 7.0, 37°C | Escherichia coli | N7-(1-(naphthalen-1-yl)ethyl)-N7-propylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00098 | - |
pH 7.0, 37°C | Homo sapiens | N7-[1-(2-ethoxynaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.001 | - |
pH 7.0, 37°C | Homo sapiens | N7-ethyl-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.001 | - |
pH 7.0, 37°C | Homo sapiens | N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.001 | - |
pH 7.0, 37°C | Escherichia coli | N7-(2-ethoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00103 | - |
pH 7.0, 37°C | Escherichia coli | N7-[2-(4-fluorophenyl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0011 | - |
pH 7.0, 37°C | Escherichia coli | N7-[1-(2-ethoxynaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0016 | - |
pH 7.0, 37°C | Homo sapiens | 6-([phenyl(propyl)amino]methyl)pteridine-2,4-diamine | |
0.0017 | - |
pH 7.0, 37°C | Homo sapiens | 6-([butyl(phenyl)amino]methyl)pteridine-2,4-diamine | |
0.0017 | - |
pH 7.0, 37°C | Escherichia coli | 2-(2-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)ethoxy)ethanol | |
0.00184 | - |
pH 7.0, 37°C | Escherichia coli | N7-butyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00185 | - |
pH 7.0, 37°C | Escherichia coli | N7-pentyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.002 | - |
pH 7.0, 37°C | Homo sapiens | 6-([phenyl(prop-2-en-1-yl)amino]methyl)pteridine-2,4-diamine | |
0.002 | - |
pH 7.0, 37°C | Homo sapiens | N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.002 | - |
pH 7.0, 37°C | Homo sapiens | N7-[1-(1-benzothiophen-3-yl)ethyl]-N7-ethylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.002 | - |
pH 7.0, 37°C | Escherichia coli | N7-(2-aminoethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0022 | - |
pH 7.0, 37°C | Escherichia coli | 6-[(phenylamino)methyl]pteridine-2,4-diamine | |
0.0022 | - |
pH 7.0, 37°C | Escherichia coli | methyl 4-([(2,4-diaminopteridin-6-yl)methyl](methyl)amino)benzoate | |
0.0022 | - |
pH 7.0, 37°C | Escherichia coli | N7-[1-(4-chloronaphthalen-1-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0025 | - |
pH 7.0, 37°C | Escherichia coli | N7-[2-(cyclohex-2-en-1-yl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.00273 | - |
pH 7.0, 37°C | Escherichia coli | 4-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)butanoic acid | |
0.0028 | - |
pH 7.0, 37°C | Homo sapiens | N7-(4-aminobutyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.003 | - |
pH 7.0, 37°C | Escherichia coli | N7-[1-(2-ethylnaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.003 | - |
pH 7.0, 37°C | Escherichia coli | N7-(5-aminopentyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0032 | - |
pH 7.0, 37°C | Escherichia coli | N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0033 | - |
pH 7.0, 37°C | Escherichia coli | N7-(2-propoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0034 | - |
pH 7.0, 37°C | Escherichia coli | N7-[3-(2-methylpropoxy)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0035 | - |
pH 7.0, 37°C | Escherichia coli | N7-methyl-N7-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylmethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0035 | - |
pH 7.0, 37°C | Escherichia coli | N7-(cyclopropylmethyl)-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0035 | - |
pH 7.0, 37°C | Escherichia coli | N7-(3-ethoxypropyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0039 | - |
pH 7.0, 37°C | Homo sapiens | N7-(5-aminopentyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.004 | - |
pH 7.0, 37°C | Escherichia coli | N7-cyclopropyl-N7-(1-(naphthalen-2-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.004 | - |
pH 7.0, 37°C | Homo sapiens | N7-butyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0046 | - |
pH 7.0, 37°C | Homo sapiens | 6-[(phenylamino)methyl]pteridine-2,4-diamine | |
0.0048 | - |
pH 7.0, 37°C | Escherichia coli | N7-(4-aminobutyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0049 | - |
pH 7.0, 37°C | Homo sapiens | N7-(2-ethoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0068 | - |
pH 7.0, 37°C | Escherichia coli | (4-(1-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]ethyl)phenyl)methanol | |
0.0078 | - |
pH 7.0, 37°C | Homo sapiens | N7-[2-(cyclohex-2-en-1-yl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.008 | - |
pH 7.0, 37°C | Homo sapiens | N7-(cyclopropylmethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0083 | - |
pH 7.0, 37°C | Escherichia coli | N-(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)-N-[1-(2-ethoxynaphthalen-1-yl)ethyl]-b-alanine | |
0.0088 | - |
pH 7.0, 37°C | Homo sapiens | N7-methyl-N7-[1-(quinolin-4-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.009 | - |
pH 7.0, 37°C | Homo sapiens | N7-methyl-N7-(1-phenylethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.009 | - |
pH 7.0, 37°C | Homo sapiens | N7-methyl-N7-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylmethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.009 | - |
pH 7.0, 37°C | Homo sapiens | N7-pentyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.01 | - |
pH 7.0, 37°C | Homo sapiens | 2-(2-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)ethoxy)ethanol | |
0.011 | - |
pH 7.0, 37°C | Escherichia coli | 6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-ylamino]methyl)pteridine-2,4-diamine | |
0.0112 | - |
pH 7.0, 37°C | Escherichia coli | N7-methyl-N7-(1-phenylethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0124 | - |
pH 7.0, 37°C | Homo sapiens | N7-[3-(2-methyl-4H-imidazol-4-yl)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0125 | - |
pH 7.0, 37°C | Homo sapiens | N7-(cyclopropylmethyl)-N7-[1-(4-methylnaphthalen-1-yl)ethyl]pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0125 | - |
pH 7.0, 37°C | Homo sapiens | N7-[1-(4-chloronaphthalen-1-yl)ethyl]-N7-(cyclopropylmethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0125 | - |
pH 7.0, 37°C | Homo sapiens | N7-[2-(4-fluorophenyl)ethyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.013 | - |
pH 7.0, 37°C | Homo sapiens | 2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]ethanol | |
0.013 | - |
pH 7.0, 37°C | Homo sapiens | N7-benzyl-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0136 | - |
pH 7.0, 37°C | Homo sapiens | N-(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)-N-[1-(2-ethoxynaphthalen-1-yl)ethyl]-b-alanine | |
0.014 | - |
pH 7.0, 37°C | Escherichia coli | 6-([(4-ethoxyphenyl)amino]methyl)pteridine-2,4-diamine | |
0.014 | - |
pH 7.0, 37°C | Homo sapiens | 6-([(4-aminophenyl)amino]methyl)pteridine-2,4-diamine | |
0.0141 | - |
pH 7.0, 37°C | Homo sapiens | 2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]-2-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethanol | |
0.015 | - |
pH 7.0, 37°C | Homo sapiens | N7-(1-(naphthalen-1-yl)ethyl)-N7-propylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.015 | - |
pH 7.0, 37°C | Homo sapiens | N7-(prop-2-en-1-yl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.015 | - |
pH 7.0, 37°C | Homo sapiens | N7-cyclopropyl-N7-(1-(naphthalen-2-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.016 | - |
pH 7.0, 37°C | Homo sapiens | 6-([(4-ethoxyphenyl)amino]methyl)pteridine-2,4-diamine | |
0.016 | - |
pH 7.0, 37°C | Homo sapiens | N7-methyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.017 | - |
pH 7.0, 37°C | Homo sapiens | N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.019 | - |
pH 7.0, 37°C | Escherichia coli | 1-(3-([(2,4-diaminopteridin-6-yl)methyl]amino)phenyl)ethanol | |
0.0191 | - |
pH 7.0, 37°C | Homo sapiens | 4-((5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-(naphthalen-1-yl)ethyl)amino)butanoic acid | |
0.021 | - |
pH 7.0, 37°C | Homo sapiens | 6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-ylamino]methyl)pteridine-2,4-diamine | |
0.021 | - |
pH 7.0, 37°C | Escherichia coli | [(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]acetic acid | |
0.0214 | - |
pH 7.0, 37°C | Escherichia coli | N7-ethyl-N7-(4-methylbenzyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.022 | - |
pH 7.0, 37°C | Homo sapiens | N-(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)-N-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethyl)-beta-alanine | |
0.0278 | - |
pH 7.0, 37°C | Homo sapiens | N7-[1-(2-ethylnaphthalen-1-yl)ethyl]-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0294 | - |
pH 7.0, 37°C | Homo sapiens | N7-(2-propoxyethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.032 | - |
pH 7.0, 37°C | Homo sapiens | N7-(3-ethoxypropyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.033 | - |
pH 7.0, 37°C | Homo sapiens | N7-ethyl-N7-(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.034 | - |
pH 7.0, 37°C | Homo sapiens | N7-[3-(2-methylpropoxy)propyl]-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.0357 | - |
pH 7.0, 37°C | Escherichia coli | N7-benzyl-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.048 | - |
pH 7.0, 37°C | Escherichia coli | 6-([tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-ylamino]methyl)pteridine-2,4-diamine | |
0.059 | - |
pH 7.0, 37°C | Homo sapiens | [(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(1-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-8-yl]ethyl)amino]acetic acid | |
0.076 | - |
pH 7.0, 37°C | Escherichia coli | 2-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]-2-[tricyclo[4.4.0.02,5]deca-1(10),2(5),6,8-tetraen-7-yl]ethanol | |
0.082 | - |
pH 7.0, 37°C | Homo sapiens | N7-benzyl-N7-methylpyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.09 | - |
pH 7.0, 37°C | Homo sapiens | (4-(1-[(5,7-diaminopyrimido[4,5-d]pyrimidin-2-yl)(methyl)amino]ethyl)phenyl)methanol | |
0.1 | - |
pH 7.0, 37°C | Homo sapiens | 1-(3-([(2,4-diaminopteridin-6-yl)methyl]amino)phenyl)ethanol | |
0.1 | - |
pH 7.0, 37°C | Escherichia coli | 6-([(4-aminophenyl)amino]methyl)pteridine-2,4-diamine | |
0.1 | - |
pH 7.0, 37°C | Homo sapiens | N7-(2-aminoethyl)-N7-(1-(naphthalen-1-yl)ethyl)pyrimido[4,5-d]pyrimidine-2,4,7-triamine | |
0.1 | - |
pH 7.0, 37°C | Escherichia coli | 6-[(tricyclo[4.3.0.07,9]nona-1,3,5-trien-3-ylamino)methyl]pteridine-2,4-diamine |