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Literature summary for 1.5.1.3 extracted from

  • Schousboe, M.L.; Rajakaruna, R.S.; Salanti, A.; Hapuarachchi, H.C.; Galappaththy, G.N.; Bygbjerg, I.C.; Amerasinghe, P.H.; Konradsen, F.; Alifrangis, M.
    Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka (2007), Malar. J., 6, 28.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine in 451 blood samples from Plasmodium vivax cases in Sri Lanka, 68.9% showed dihydrofolate reductase wild-type haplotype. The double mutant F57L/S58R haplotype was the most frequently observed mutant with 24.4%, while the triple mutant F57L/S58R/S117N was only identified once. A significantly higher frequency of mutant haplotypes is observed in the Northern districts Plasmodium vivax

Organism

Organism UniProt Comment Textmining
Plasmodium vivax
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isolates from Sri Lanka
-