Any feedback?
Literature summary for 1.5.1.3 extracted from
- Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase (2007), J. Med. Chem., 50, 4374-4381.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with methotrexate, at 2.4 A resolution. Modeling of inhibitor 5-nitro-6-methylamino-isocytosine into the active site reveals four potential hydrogen bonds | Bacillus anthracis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-nitro-6-methylamino-isocytosine | inhibitor of dihydropteroate synthase, also acts on dihydrofolate reductase | Bacillus anthracis |  |
| methotrexate | - |
Bacillus anthracis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | Q81R22 | - |
- |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
