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Literature summary for 1.5.1.3 extracted from

  • Pu, J.; Ma, S.; Garcia-Viloca, M.; Gao, J.; Truhlar, D.G.; Kohen, A.
    Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase (2005), J. Am. Chem. Soc., 127, 14879-14886.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Reaction

Reaction Comment Organism Reaction ID
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ donor carbon at the hydride transfer transition state resembles the reactant state more than the product state, whereas the acceptor carbon is more productlike, a symptom of transition state imbalance Escherichia coli