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Literature summary for 1.5.1.21 extracted from
- Lysine metabolism in mammalian brain an update on the importance of recent discoveries (2013), Amino Acids, 45, 1249-1272 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| cytosol | - |
Bos taurus | 5829 | - |
| soluble | - |
Mus musculus | - |
- |
| soluble | - |
Rattus norvegicus | - |
- |
| soluble | - |
Sus scrofa | - |
- |
| soluble | - |
Bos taurus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
- |
Bos taurus |
| 70000 | - |
- |
Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-piperideine-2-carboxylate + NADPH + H+ | Mus musculus | - |
L-pipecolate + NADP+ | - |
r |  |
| 1-piperideine-2-carboxylate + NADPH + H+ | Rattus norvegicus | - |
L-pipecolate + NADP+ | - |
r | |
| 1-piperideine-2-carboxylate + NADPH + H+ | Sus scrofa | - |
L-pipecolate + NADP+ | - |
r | |
| 1-piperideine-2-carboxylate + NADPH + H+ | Bos taurus | - |
L-pipecolate + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | Mus musculus | - |
L-proline + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | Rattus norvegicus | - |
L-proline + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | Sus scrofa | - |
L-proline + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | Bos taurus | - |
L-proline + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from kidney | Sus scrofa |
| native enzyme from kidney | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
| brain | especially in frontal and temporal cortex, the level of L-pipecolate is highest in the cerebellum | Rattus norvegicus | - |
| brain | especially in frontal and temporal cortex, with the striatum having the maximal specific activity. Both the level of L-pipecolate and P2C/Pyr2C reductase-specific activity differed considerably among the different brain regions | Mus musculus | - |
| cerebellum | - |
Bos taurus | - |
| kidney | high enzyme activity | Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-piperideine-2-carboxylate + NADPH + H+ | - |
Mus musculus | L-pipecolate + NADP+ | - |
r | |
| 1-piperideine-2-carboxylate + NADPH + H+ | - |
Rattus norvegicus | L-pipecolate + NADP+ | - |
r | |
| 1-piperideine-2-carboxylate + NADPH + H+ | - |
Sus scrofa | L-pipecolate + NADP+ | - |
r | |
| 1-piperideine-2-carboxylate + NADPH + H+ | - |
Bos taurus | L-pipecolate + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | - |
Mus musculus | L-proline + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | - |
Rattus norvegicus | L-proline + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | - |
Sus scrofa | L-proline + NADP+ | - |
r | |
| 1-pyrroline-2-carboxylate + NADPH + H+ | - |
Bos taurus | L-proline + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ketimine reductase | - |
Mus musculus |
| ketimine reductase | - |
Rattus norvegicus |
| ketimine reductase | - |
Sus scrofa |
| ketimine reductase | - |
Bos taurus |
| P2C reductase | - |
Mus musculus |
| P2C reductase | - |
Rattus norvegicus |
| P2C reductase | - |
Sus scrofa |
| P2C reductase | - |
Bos taurus |
| P2C/Pyr2C reductase | - |
Mus musculus |
| P2C/Pyr2C reductase | - |
Rattus norvegicus |
| P2C/Pyr2C reductase | - |
Sus scrofa |
| P2C/Pyr2C reductase | - |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
reduction of 1-piperideine-2-carboxylate | Bos taurus |
| 5.2 | - |
reduction of 1-piperideine-2-carboxylate | Mus musculus |
| 5.2 | - |
reduction of 1-piperideine-2-carboxylate | Rattus norvegicus |
| 5.4 | - |
reduction of 1-pyrroline-2-carboxylate | Mus musculus |
| 5.4 | - |
reduction of 1-pyrroline-2-carboxylate | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme purified from bovine cerebellum exhibits a marked preference for NADPH over NADH with substrate 1-piperideine-2-carboxylate | Bos taurus | |
| additional information | the enzyme purified from porcine kidney exhibits a marked preference for NADPH over NADH | Sus scrofa | |
| NADPH | - |
Mus musculus | |
| NADPH | - |
Rattus norvegicus | |
| NADPH | - |
Sus scrofa | |
| NADPH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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