Literature summary for 1.5.1.20 extracted from

Ozbek, Z.; Kucukali, C.I.; Ozkok, E.; Orhan, N.; Aydin, M.; Kilic, G.; Sazci, A.; Kara, I.
Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives (2008), Prog. Neuropsychopharmacol. Biol. Psychiatry, 32, 1331-1337.

Search for more literature for 1.5.1.20

Protein Variants

Protein Variants	Comment	Organism
A222V	the muattion leads to elevated total homocysteine concentration and reduced folate and vitamin B12 levels, but is not associated with the development of bipolar disorders	Homo sapiens
E429D	the muattion leads to elevated total homocysteine concentration and reduced folate and vitamin B12 levels, but is not associated with the development of bipolar disorders	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + reduced acceptor	-	Homo sapiens	5-methyltetrahydrofolate + oxidized acceptor	-	ir

Synonyms

Synonyms	Comment	Organism
methylenetetrahydrofolate reductase	-	Homo sapiens
MTHFR	-	Homo sapiens

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Release 2023.1 (January 2023)