Protein Variants | Comment | Organism |
---|---|---|
additional information | C677T mutation of the gene for methylenetetrahydrofolate reductase: thermolabile enzyme with reduced activity, due to the loss of its riboflavin cofactor, homozygous genotype TT is associated with an increase in plasma total homocysteine, 12% of the healthy white population with this polymorphism | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + reduced acceptor | Homo sapiens | supply of the folate needed for the metabolism of homocysteine: 5-methyltetrahydrofolate is required for the methylation of homocysteine to methionine | 5-methyltetrahydrofolate + oxidized acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
healthy men and women aged 19-63 years | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + reduced acceptor | forward reaction: reduced acceptor is FADH2 | Homo sapiens | 5-methyltetrahydrofolate + oxidized acceptor | - |
? | |
5,10-methylenetetrahydrofolate + reduced acceptor | supply of the folate needed for the metabolism of homocysteine: 5-methyltetrahydrofolate is required for the methylation of homocysteine to methionine | Homo sapiens | 5-methyltetrahydrofolate + oxidized acceptor | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | requires FAD as cofactor | Homo sapiens | |
FADH2 | - |
Homo sapiens |