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Literature summary for 1.5.1.2 extracted from
- Human pyrroline-5-carboxylate reductase (PYCR1) acts on delta(1)-piperideine-6-carboxylate generating L-pipecolic acid (2014), J. Inherit. Metab. Dis., 37, 327-332.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DL-pipecolic acid | 65% inhibition at 10mM | Homo sapiens |  |
| L-proline | 94% inhibition at 10 mM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| piperideine-6-carboxylate + NADH + H+ | - |
Homo sapiens | L-pipecolic acid + NAD+ | L-pipecolic acid is the sole product | ir | |
| piperideine-6-carboxylate + NADPH + H+ | - |
Homo sapiens | L-pipecolic acid + NADP+ | L-pipecolic acid is the sole product | ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pycr1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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