Inhibitors | Comment | Organism | Structure |
---|---|---|---|
([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid) | 71.2% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | 95.4% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | 52% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | 63.9% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | 96.2% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | 92.5% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid) | 98.4% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | 91.1% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid) | 70.5% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid) | 71.2% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid) | 94.5% inhibition at 0.2 mM | Streptococcus pyogenes | |
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid) | 61.5% inhibition at 0.2 mM | Streptococcus pyogenes |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-pyrroline-5-carboxylate + NAD(P)H + H+ | Streptococcus pyogenes | - |
L-proline + NAD(P)+ | - |
? | |
1-pyrroline-5-carboxylate + NAD(P)H + H+ | Streptococcus pyogenes ATCC 19615 | - |
L-proline + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes | - |
- |
- |
Streptococcus pyogenes ATCC 19615 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
nickel affinity gel column chromatography | Streptococcus pyogenes |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-pyrroline-5-carboxylate + NAD(P)H + H+ | - |
Streptococcus pyogenes | L-proline + NAD(P)+ | - |
? | |
1-pyrroline-5-carboxylate + NAD(P)H + H+ | - |
Streptococcus pyogenes ATCC 19615 | L-proline + NAD(P)+ | - |
? | |
1-pyrroline-5-carboxylate + NADH + H+ | - |
Streptococcus pyogenes | L-proline + NAD+ | - |
? | |
1-pyrroline-5-carboxylate + NADH + H+ | - |
Streptococcus pyogenes ATCC 19615 | L-proline + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DELTA1-pyrroline-5-carboxylate reductase | - |
Streptococcus pyogenes |
P5C reductase | - |
Streptococcus pyogenes |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Streptococcus pyogenes | |
NADPH | - |
Streptococcus pyogenes |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00022 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.00022 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.00039 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.00041 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid) | |
0.00078 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | ([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid) | |
0.00087 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.00088 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.0009 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.0014 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.0027 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.012 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.0256 | - |
pH 7.5-8.0, at 37°C | Streptococcus pyogenes | [[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid) |