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Literature summary for 1.5.1.2 extracted from

  • Zabirnyk, O.; Liu, W.; Khalil, S.; Sharma, A.; Phang, J.M.
    Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy (2010), Carcinogenesis, 31, 446-454.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.2

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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 Homo sapiens
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HeLa cell
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 Homo sapiens
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HT-29 cell
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 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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OVCAR-3 cell
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 Homo sapiens
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OVCAR-5 cell
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 Homo sapiens
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PC-3 cell
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens oxidized low-density lipoproteins upregulate proline oxidase through nuclear receptor peroxisome proliferator-activated receptor gamma up

General Information

General Information Comment Organism
physiological function treatment with oxidized low-density lipoproteins decreases the cell number per field and causes the cells to round up. Knock-down of proline oxidase via small interfering RNA further reduces viability of cancer cells treated with oxidized low-density lipoproteins, decreases oxidized low-density lipoproteins-associated reactive oxygen species generation, decreases autophagy measured via beclin-1 protein level and light-chain 3 protein-I into LC3-II conversion. Single proline oxidase overexpression is sufficient to activate autophagy. It leads to autophagosomes accumulation and increases conversion of LC3-I into LC3-II.Beclin-1 gene expression is directly dependent on proline oxidase catalytic activity, namely the generation of prloine-oxidase-dependent superoxide Homo sapiens