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Literature summary for 1.5.1.15 extracted from

  • Patel, H.; Di Pietro, E.; Mejia, N.; MacKenzie, R.E.
    NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate dehydrogenase-cyclohydrolases can rescue mthfd2 null fibroblasts (2005), Arch. Biochem. Biophys., 442, 133-139.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K56Q inactivation of methenyltetrahydrofolate cyclohydrolase activity of bifunctional enzyme. Transfection with mutant enzyme rescues auxotrophy of enzyme-deficient fibroblasts, but only poorly. Rescued cells demonstrate a decrease in the ratio of incorporation of exogenous formate to serine Mus musculus
additional information enzyme deletion mutant, auxotroph for glycine Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Mus musculus
-