Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a gene deletion mutant cell line, the cells can survive in liver and other tissues because the null defect is rescued by metabolites supplied by surrounding normal cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + NAD+ | Mus musculus | enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview | 5,10-methenyltetrahydrofolate + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P18155 | gene nmdmc | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | enzyme is mainly expressed during embryogenesis for purine synthesis | Mus musculus | - |
liver | - |
Mus musculus | - |
additional information | expression pattern analysis, elevated enzyme expression in tumour cells due to different folate-mediated support of purine synthesis compared to normal cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + NAD+ | - |
Mus musculus | 5,10-methenyltetrahydrofolate + NADH | - |
? | |
5,10-methylenetetrahydrofolate + NAD+ | enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview | Mus musculus | 5,10-methenyltetrahydrofolate + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methylenetetrahydrofolate dehydrogenase-cyclohydrolase | - |
Mus musculus |
NMDMC | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Mus musculus |