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Literature summary for 1.5.1.15 extracted from

  • Yang, X.M.; Mackenzie, R.E.
    NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene (1993), Biochemistry, 32, 11118-11123.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphate
-
Mus musculus
phosphate absolute requirement, phosphate can be replaced by its analog arsenate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme, expressed in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0046
-
L-5,10-methylenetetrahydrofolate
-
Homo sapiens
0.18
-
Mg2+
-
Homo sapiens
2.5
-
NAD+
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Saccharomyces cerevisiae 5829
-
mitochondrion
-
Mus musculus 5739
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Saccharomyces cerevisiae 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus
Mg2+ absolute requirement Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-5,10-methenyl-tetrahydrofolate + NADH Mus musculus
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH Homo sapiens
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH Saccharomyces cerevisiae
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methylenetetrahydrofolate + NAD+ Mus musculus
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+ Homo sapiens
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+ Saccharomyces cerevisiae
-
5,10-methenyl-tetrahydrofolate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Mus musculus
-
mouse, Ehrlich ascites tumor cells
-
Saccharomyces cerevisiae
-
yeast
-

Purification (Commentary)

Purification (Comment) Organism
from ascites tumor cells Mus musculus
recombinant enzyme, expressed in Escherichia coli Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Ehrlich ascites carcinoma cell
-
Mus musculus
-
fetus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-5,10-methenyl-tetrahydrofolate + NADH
-
Mus musculus L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH
-
Homo sapiens L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH
-
Saccharomyces cerevisiae L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methylenetetrahydrofolate + NAD+
-
Mus musculus 5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+
-
Homo sapiens 5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+
-
Saccharomyces cerevisiae 5,10-methenyl-tetrahydrofolate + NADH
-
r
additional information
-
Mus musculus ?
-
?
additional information
-
Saccharomyces cerevisiae ?
-
?
additional information bifunctional enzyme Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Mg2+-/phosphate-dependent dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NAD+
-
Saccharomyces cerevisiae
NAD+ NAD+ cofactor can be replaced by NADP+ Homo sapiens