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Literature summary for 1.5.1.11 extracted from

  • Storey, K.B.; Dando, P.R.
    Substrate specificities of octopine dehydrogenases from marine invertebrates (1982), Comp. Biochem. Physiol. B, 73, 521-528.
No PubMed abstract available
Search for more literature for 1.5.1.11

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Pecten maximus
additional information
-
 additional information
-
 Calliactis parasitica
additional information
-
 additional information
-
 Arctica islandica
0.1
-
 D-octopine brain enzyme Sepia officinalis
0.6
-
 pyruvate pyruvate Mytilus edulis
0.6
-
 pyruvate brain enzyme Sepia officinalis
0.6
-
 pyruvate oxaloacetate Mytilus edulis
0.8
-
 pyruvate
-
 Mytilus edulis
0.8
-
 pyruvate
-
 Cerastoderma edule
0.8
-
 pyruvate
-
 Glycymeris glycymeris
0.9
-
 Arg
-
 Mytilus edulis
0.9
-
 Arg oxaloacetate Cerastoderma edule
0.9
-
 Arg D-octopine, mantle enzyme Sepia officinalis
1
-
 oxaloacetate
-
 Glycymeris glycymeris
1.4
-
 L-Arg pyruvate, mantle enzyme Sepia officinalis
1.4
-
 L-Arg with pyruvate as cosubstrate Mytilus edulis
1.5
-
 D-octopine
-
 Pecten maximus
1.5
-
 D-octopine
-
 Glycymeris glycymeris
1.6
-
 oxaloacetate brain enzyme Sepia officinalis
1.8
-
 Lys
-
 Mytilus edulis
1.8
-
 Lys L-Arg, with pyruvate as cosubstrate Glycymeris glycymeris
2
-
 D-octopine L-Arg, with pyruvate as cosubstrate, brain enzyme Sepia officinalis
2.2
-
 L-Arg with 2-ketobutanoate as cosubstrate Glycymeris glycymeris
2.4
-
 NADH
-
 Glycymeris glycymeris
2.5
-
 Arg L-Arg, with oxaloacetate as cosubstrate Mytilus edulis
2.5
-
 Arg L-Lys, brain enzyme Sepia officinalis
2.6
-
 oxaloacetate D-lysopine, brain enzyme Sepia officinalis
2.6
-
 oxaloacetate mantle enzyme Sepia officinalis
3
-
 L-Arg with pyruvate as cosubstrate Cerastoderma edule
3.1
-
 pyruvate D-octopine Mytilus edulis
3.2
-
 D-lysopine
-
 Glycymeris glycymeris
3.2
-
 D-lysopine
-
 Sepia officinalis
3.3
-
 L-Lys
-
 Mytilus edulis
3.7
-
 L-Arg L-Lys Glycymeris glycymeris
3.7
-
 L-Arg with 2-ketobutanoate as cosubstrate Mytilus edulis
3.8
-
 L-Arg with 2-ketobutanoate as cosubstrate Cerastoderma edule
4
-
 L-Arg with oxaloacetate as cosubstrate Cerastoderma edule
5
-
 L-Arg with oxaloacetate as cosubstrate Mytilus edulis
5.2
-
 D-octopine
-
 Cerastoderma edule
5.3
-
 L-Arg with 2-ketobutanoate as cosubstrate, brain enzyme Sepia officinalis
5.5
-
 L-Arg with pyruvate as cosubstrate, mantle enzyme Sepia officinalis
5.8
-
 NADH
-
 Mytilus edulis
6.1
-
 L-Lys mantle enzyme Sepia officinalis
6.1
-
 L-Lys 2-ketobutanoate, brain enzyme Sepia officinalis
6.2
-
 2-oxobutanoate
-
 Cerastoderma edule
6.2
-
 L-Arg with 2-oxobutanoate as cosubstrate, mantle enzyme Sepia officinalis
6.4
-
 D-lysopine
-
 Mytilus edulis
7.3
-
 2-oxobutanoate
-
 Mytilus edulis
7.8
-
 2-oxobutanoate mantle enzyme Sepia officinalis
8
-
 L-Arg 2-ketobutanoate Glycymeris glycymeris
8
-
 L-Arg with oxaloacetate as cosubstrate, mantle enzyme Sepia officinalis
12
-
 L-Arg with oxaloacetate as cosubstrate, brain enzyme Sepia officinalis
13
-
 NADH
-
 Cerastoderma edule
15
-
 NADH brain enzyme Sepia officinalis
18
-
 NADH mantle enzyme Sepia officinalis
25
-
 L-Orn brain enzyme Sepia officinalis
28
-
 L-Orn
-
 Cerastoderma edule
48
-
 NAD+ brain enzyme Sepia officinalis
65
-
 NAD+
-
 Mytilus edulis
75
-
 NAD+
-
 Glycymeris glycymeris
110
-
 NAD+ NAD+ Cerastoderma edule
110
-
 NAD+ mantle enzyme Sepia officinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mytilus edulis the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups ?
-
 ?
additional information Cerastoderma edule the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups ?
-
 ?
additional information Glycymeris glycymeris the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups ?
-
 ?
additional information Sepia officinalis the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups ?
-
 ?
additional information Sepia officinalis major physiological role in glycolytic energy poduction during burst swimming ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arctica islandica
-
-
-
Calliactis parasitica
-
-
-
Cerastoderma edule
-
-
-
Glycymeris glycymeris
-
-
-
Mytilus edulis
-
-
-
Pecten maximus
-
-
-
Sepia officinalis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adductor
-
 Pecten maximus
-
adductor
-
 Mytilus edulis
-
adductor
-
 Cerastoderma edule
-
brain
-
 Sepia officinalis
-
foot muscle
-
 Mytilus edulis
-
foot muscle
-
 Cerastoderma edule
-
foot muscle
-
 Glycymeris glycymeris
-
foot muscle
-
 Arctica islandica
-
mantle muscle
-
 Calliactis parasitica
-
mantle muscle
-
 Sepia officinalis
-
pedal muscle
-
 Calliactis parasitica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Canavanine + pyruvate + NADH
-
 Mytilus edulis N2-(D-1-Carboxyethyl)-canavanine + NAD+ + H2O
-
 ?
Canavanine + pyruvate + NADH
-
 Calliactis parasitica N2-(D-1-Carboxyethyl)-canavanine + NAD+ + H2O
-
 ?
Canavanine + pyruvate + NADH
-
 Cerastoderma edule N2-(D-1-Carboxyethyl)-canavanine + NAD+ + H2O
-
 ?
Canavanine + pyruvate + NADH
-
 Glycymeris glycymeris N2-(D-1-Carboxyethyl)-canavanine + NAD+ + H2O
-
 ?
Canavanine + pyruvate + NADH
-
 Sepia officinalis N2-(D-1-Carboxyethyl)-canavanine + NAD+ + H2O
-
 ?
Canavanine + pyruvate + NADH
-
 Arctica islandica N2-(D-1-Carboxyethyl)-canavanine + NAD+ + H2O
-
 ?
Homoarginine + pyruvate + NADH
-
 Mytilus edulis N2-(D-1-Carboxyethyl)-homoarginine + NAD+ + H2O
-
 ?
Homoarginine + pyruvate + NADH
-
 Calliactis parasitica N2-(D-1-Carboxyethyl)-homoarginine + NAD+ + H2O
-
 ?
Homoarginine + pyruvate + NADH
-
 Cerastoderma edule N2-(D-1-Carboxyethyl)-homoarginine + NAD+ + H2O
-
 ?
Homoarginine + pyruvate + NADH
-
 Glycymeris glycymeris N2-(D-1-Carboxyethyl)-homoarginine + NAD+ + H2O
-
 ?
Homoarginine + pyruvate + NADH
-
 Sepia officinalis N2-(D-1-Carboxyethyl)-homoarginine + NAD+ + H2O
-
 ?
Homoarginine + pyruvate + NADH
-
 Arctica islandica N2-(D-1-Carboxyethyl)-homoarginine + NAD+ + H2O
-
 ?
L-Arg + 2-oxobutanoate + NADH
-
 Mytilus edulis N2-(D-2-Carboxypropyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + 2-oxobutanoate + NADH
-
 Calliactis parasitica N2-(D-2-Carboxypropyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + 2-oxobutanoate + NADH
-
 Cerastoderma edule N2-(D-2-Carboxypropyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + 2-oxobutanoate + NADH
-
 Glycymeris glycymeris N2-(D-2-Carboxypropyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + 2-oxobutanoate + NADH
-
 Sepia officinalis N2-(D-2-Carboxypropyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + 2-oxobutanoate + NADH
-
 Arctica islandica N2-(D-2-Carboxypropyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + oxaloacetate + NADH
-
 Mytilus edulis ?
-
 ?
L-Arg + oxaloacetate + NADH
-
 Calliactis parasitica ?
-
 ?
L-Arg + oxaloacetate + NADH
-
 Cerastoderma edule ?
-
 ?
L-Arg + oxaloacetate + NADH
-
 Glycymeris glycymeris ?
-
 ?
L-Arg + oxaloacetate + NADH
-
 Sepia officinalis ?
-
 ?
L-Arg + oxaloacetate + NADH
-
 Arctica islandica ?
-
 ?
L-Arg + pyruvate + NADH
-
 Cerastoderma edule N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + pyruvate + NADH
-
 Glycymeris glycymeris N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + pyruvate + NADH
-
 Sepia officinalis N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + pyruvate + NADH
-
 Arctica islandica N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + pyruvate + NADH r Pecten maximus N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + pyruvate + NADH r Mytilus edulis N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
L-Arg + pyruvate + NADH r Calliactis parasitica N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
L-Lys + pyruvate + NADH
-
 Sepia officinalis Lysopine + NAD+ + H2O
-
 ?
L-Lys + pyruvate + NADH no activity Pecten maximus Lysopine + NAD+ + H2O
-
 ?
L-Lys + pyruvate + NADH no activity Cerastoderma edule Lysopine + NAD+ + H2O
-
 ?
L-Lys + pyruvate + NADH no activity Arctica islandica Lysopine + NAD+ + H2O
-
 ?
L-Lys + pyruvate + NADH r Mytilus edulis Lysopine + NAD+ + H2O
-
 ?
L-Lys + pyruvate + NADH r Calliactis parasitica Lysopine + NAD+ + H2O
-
 ?
L-Lys + pyruvate + NADH r Glycymeris glycymeris Lysopine + NAD+ + H2O
-
 ?
additional information the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups Mytilus edulis ?
-
 ?
additional information the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups Cerastoderma edule ?
-
 ?
additional information the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups Glycymeris glycymeris ?
-
 ?
additional information the evolutionary development of the enzyme appears to have led from a broadly specific imino acid dehydrogenase in sea anemones to enzymes increasingly specific for the substrate L-Arg, and pyruvate only. This trend is correlated with an increasing importance of the enzyme in glycolytic redox balance in working muscle and an increased dependence on muscle arginine phosphate reserves for rapid energy generation in higher invertebrate groups Sepia officinalis ?
-
 ?
additional information major physiological role in glycolytic energy poduction during burst swimming Sepia officinalis ?
-
 ?
Orn + pyruvate + NADH
-
 Mytilus edulis N2-(D-1-Carboxyethyl)-L-Orn + NAD+ + H2O
-
 ?
Orn + pyruvate + NADH
-
 Calliactis parasitica N2-(D-1-Carboxyethyl)-L-Orn + NAD+ + H2O
-
 ?
Orn + pyruvate + NADH
-
 Cerastoderma edule N2-(D-1-Carboxyethyl)-L-Orn + NAD+ + H2O
-
 ?
Orn + pyruvate + NADH
-
 Glycymeris glycymeris N2-(D-1-Carboxyethyl)-L-Orn + NAD+ + H2O
-
 ?
Orn + pyruvate + NADH no activity Pecten maximus N2-(D-1-Carboxyethyl)-L-Orn + NAD+ + H2O
-
 ?
Orn + pyruvate + NADH no activity Arctica islandica N2-(D-1-Carboxyethyl)-L-Orn + NAD+ + H2O
-
 ?
Orn + pyruvate + NADH activity with brain enzyme, no activity with mantle enzyme Sepia officinalis N2-(D-1-Carboxyethyl)-L-Orn + NAD+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Pecten maximus
NADH
-
 Mytilus edulis
NADH
-
 Calliactis parasitica
NADH
-
 Cerastoderma edule
NADH
-
 Glycymeris glycymeris
NADH
-
 Sepia officinalis
NADH
-
 Arctica islandica