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Literature summary for 1.5.1.10 extracted from

  • Vashishtha, A.K.; West, A.H.; Cook, P.F.
    Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae (2009), Biochemistry, 48, 5899-5907.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
glyoxylate
-
Saccharomyces cerevisiae
NADPH
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
Saccharomyces cerevisiae L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
saccharopine dehydrogenase
-
Saccharomyces cerevisiae
saccharopine dehydrogenase (L-glutamate forming)
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Saccharomyces cerevisiae