Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | ANR, anaerobic regulator required for maximal expression of the HCN biosynthetic genes | Pseudomonas fluorescens |
Cloned (Comment) | Organism |
---|---|
hcnABC gene cluster encoding hydrogen cyanide synthase, heterologously expressed in Escherichia coli | Pseudomonas fluorescens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
O2 | - |
Pseudomonas aeruginosa | |
O2 | very sensitive to molecular oxygen, becomes rapidly inactivated in presence | Pseudomonas fluorescens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | iron regulation of the hcnABC genes encoding hydrogen cyanide synthase, iron limitation has negative effect on hcn expression | Pseudomonas fluorescens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycine + O2 | Pseudomonas fluorescens | - |
HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | Pseudomonas aeruginosa | - |
HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | Chromobacterium violaceum | - |
HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | Pseudomonas aeruginosa PAO1A4 | - |
HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | Pseudomonas fluorescens CHA0 | - |
HCN + CO2 + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chromobacterium violaceum | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas aeruginosa | - |
wild-type PAO1 | - |
Pseudomonas aeruginosa PAO1A4 | - |
- |
- |
Pseudomonas fluorescens | - |
- |
- |
Pseudomonas fluorescens CHA0 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycine + O2 | - |
Pseudomonas fluorescens | HCN + CO2 + H2O | - |
? | |
glycine + O2 | - |
Pseudomonas aeruginosa | HCN + CO2 + H2O | - |
? | |
glycine + O2 | - |
Chromobacterium violaceum | HCN + CO2 + H2O | - |
? | |
glycine + O2 | - |
Pseudomonas aeruginosa PAO1A4 | HCN + CO2 + H2O | - |
? | |
glycine + O2 | - |
Pseudomonas fluorescens CHA0 | HCN + CO2 + H2O | - |
? | |
glycine + O2 | - |
Pseudomonas fluorescens | HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | - |
Pseudomonas aeruginosa | HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | - |
Chromobacterium violaceum | HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | - |
Pseudomonas aeruginosa PAO1A4 | HCN + CO2 + 2 H2O | - |
? | |
glycine + O2 | - |
Pseudomonas fluorescens CHA0 | HCN + CO2 + 2 H2O | - |
? |