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Literature summary for 1.4.4.2 extracted from

  • Alptekin, A.; Ye, B.; Yu, Y.; Poole, C.J.; van Riggelen, J.; Zha, Y.; Ding, H.F.
    Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity (2019), Oncogene, 38, 7504-7520 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
diagnostics high glycine decarboxylase expression is associated with poor prognosis and advanced stages of neuroblastoma. MYCN amplification is a biomarker for glycine decarboxylase-based therapeutic strategies against high-risk neuroblastoma Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P23378
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-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell line
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
GLDC
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 Homo sapiens
glycine decarboxylase
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens glycine decarboxylase (GLDC) is a direct transcriptional target of MYCN. As a result, GLDC expression is markedly elevated in neuroblastoma tumors and cell lines amplified by the oncogene up

General Information

General Information Comment Organism
malfunction glycine decarboxylase (GLDC) knockdown disrupts purine and central carbon metabolism and reduces citrate production, leading to a decrease in the steady-state levels of cholesterol and fatty acids Homo sapiens
physiological function the enzyme catalyzes the first and rate-limiting step in glycine breakdown with the production of the one-carbon unit 5,10-methylene-tetrahydrofolate. Critical role of the enzyme (GLDC) in sustaining the proliferation of neuroblastoma cells with high-level GLDC expression Homo sapiens