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Literature summary for 1.4.4.2 extracted from

  • Liu, R.; Zeng, L.W.; Gong, R.; Yuan, F.; Shu, H.B.; Li, S.
    mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis (2021), Nat. Commun., 12, 4227 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.4.2

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P23378
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
acetylation the activity is regulated by sequential posttranslational modifications, including acetylation and polyubiquitination, and reveal critical regulatory mechanisms of glycine metabolism and tumorigenesis. Acetylation of K514 inhibits glycine catabolism and pyrimidine synthesis. In addition, this acetylation of glycine decarboxylase also primes for its K33-linked polyubiquitination and proteasomal degradation, leading to suppression of glycine metabolism and tumorigenesis Homo sapiens
ubiquitination the activity is regulated by sequential posttranslational modifications, including acetylation and polyubiquitination (K33-linked polyubiquitination), and reveal critical regulatory mechanisms of glycine metabolism and tumorigenesis Homo sapiens

Synonyms

Synonyms Comment Organism
GLDC
-
 Homo sapiens
P protein
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate a pyridoxal-phosphate protein Homo sapiens

Expression

Organism Comment Expression
Homo sapiens glycine decarboxylase is commonly up-regulated and plays important roles in many human cancers up

General Information

General Information Comment Organism
metabolism glycine decarboxylase is a key enzyme of glycine cleavage system that converts glycine into one-carbon units Homo sapiens