Literature summary for 1.4.4.2 extracted from

Zhuang, H.; Li, Q.; Zhang, X.; Ma, X.; Wang, Z.; Liu, Y.; Yi, X.; Chen, R.; Han, F.; Zhang, N.; Li, Y.
Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells (2018), Free Radic. Biol. Med., 120, 1-12 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23378	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell line	HCC cell line	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GLDC	-	Homo sapiens
glycine decarboxylase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme promotes tumor initiation and proliferation in non-small cell lung cancer and glioma and it is a putative tumor suppressor gene in gastric cancer. Knockdown of the enzyme (GLDC) enhances cancer cell migration and invasion, GLDC overexpression inhibits them. GLDC downregulation decreases ROS-mediated ubiquitination of cofilin to enhance hepatocellular carcinoma progression and intrahepatic metastasis	Homo sapiens

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Release 2023.1 (January 2023)