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Literature summary for 1.4.4.2 extracted from

  • Hiraga, K.; Kikuchi, G.
    The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein (1980), J. Biol. Chem., 255, 11671-11676.
    View publication on PubMed
Search for more literature for 1.4.4.2

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol thiol compound required for maximal activity on glycine-CO2 exchange reaction Gallus gallus
dithiothreitol thiol compound required for maximal activity on glycine-CO2 exchange reaction Gallus gallus
GSH thiol compound required for maximal activity on glycine-CO2 exchange reaction Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
K2HPO4 inhibition of glycine-CO2 exchange reaction Gallus gallus
KCl inhibition of glycine-CO2 exchange reaction Gallus gallus
N4-methylglutamine inhibition of glycine-CO2 exchange reaction Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4
-
 CO2 glycine-CO2 exchange Gallus gallus
20
-
 glycine glycine-CO2 exchange Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + lipoylprotein Gallus gallus reaction is stimulated by lipoic acid which is a functional group of the H-protein S-aminomethyldihydrolipoylprotein + CO2
-
 ?
glycine + lipoylprotein Gallus gallus lipoyl protein: H-protein, lipoamide can also act as acceptor S-aminomethyldihydrolipoylprotein + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + lipoylprotein reaction is stimulated by lipoic acid which is a functional group of the H-protein Gallus gallus S-aminomethyldihydrolipoylprotein + CO2
-
 ?
glycine + lipoylprotein lipoyl protein: H-protein, lipoamide can also act as acceptor Gallus gallus S-aminomethyldihydrolipoylprotein + CO2
-
 ?
additional information P-protein also catalyzes exchange of carbonyl carbon of glycine with CO2, reaction greatly stimulated by addition of H protein Gallus gallus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
 glycine-CO2 exchange Gallus gallus