Cloned (Comment) | Organism |
---|---|
gene PNPO, DNA and amino acid sequence determination and analysis, expression of wild-type PNPO and mutant R229W in CHO cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
E50K | mutant shows activity similar to the wild-type enzyme | Mus musculus |
additional information | DNA sequence determination of PNPO homozygous missense, splice site and stop codon mutations involved in neonatal epileptic encephalopathy, phenotypes overview | Mus musculus |
R229W | 70% reduced activity compared to the wild-type enzyme, DNA sequence determination of PNPO homozygous missense, splice site and stop codon mutations involved in neonatal epileptic encephalopathy, phenotype overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase cause neonatal epileptic encephalopathy | ? | - |
? | |
pyridoxamine 5'-phosphate + FMN + H2O + 2 H+ | Mus musculus | - |
pyridoxal 5'-phosphate + FMNH2 + NH3 | - |
? | |
pyridoxine 5'-phosphate + FMN | Mus musculus | - |
pyridoxal 5'-phosphate + FMNH2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene PNPO | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase cause neonatal epileptic encephalopathy | Mus musculus | ? | - |
? | |
pyridoxamine 5'-phosphate + FMN + H2O + 2 H+ | - |
Mus musculus | pyridoxal 5'-phosphate + FMNH2 + NH3 | - |
? | |
pyridoxine 5'-phosphate + FMN | - |
Mus musculus | pyridoxal 5'-phosphate + FMNH2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PNPO | - |
Mus musculus |
pyridox(am)ine 5'-phosphate oxidase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FMN | - |
Mus musculus |