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Literature summary for 1.4.3.3 extracted from

  • Sasabe, J.; Miyoshi, Y.; Rakoff-Nahoum, S.; Zhang, T.; Mita, M.; Davis, B.M.; Hamase, K.; Waldor, M.K.
    Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota (2016), Nat. Microbiol., 1, 16125 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
G181R inactive Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Ala + H2O + O2 Mus musculus
-
pyruvate + NH3 + H2O2
-
?
D-Pro + H2O + O2 Mus musculus
-
2-oxopentanoic acid + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P18894
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestinal epithelial cell
-
Mus musculus
-
intestine
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ala + H2O + O2
-
Mus musculus pyruvate + NH3 + H2O2
-
?
D-Pro + H2O + O2
-
Mus musculus 2-oxopentanoic acid + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
DAO
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme plays a general role in protection at the mucosal surface. The enzyme is a microbiota-regulated host innate immune factor that modulates growth of both pathogens and commensals, primarily in the small intestine Mus musculus