Literature summary for 1.4.3.3 extracted from

Xie, D.; Lu, J.; Xie, J.; Cui, J.; Li, T.F.; Wang, Y.C.; Chen, Y.; Gong, N.; Li, X.Y.; Fu, L.; Wang, Y.X.
Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent D-amino acid oxidase inhibitor (2016), Eur. J. Med. Chem., 117, 19-32 .

Inhibitors

Inhibitors	Comment	Organism
1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylic acid	-	Homo sapiens
2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylic acid	-	Rattus norvegicus
2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylic acid	-	Sus scrofa
3-hydroxyquinolin-2-one	-	Homo sapiens
3-hydroxyquinolin-2-one	-	Rattus norvegicus
3-hydroxyquinolin-2-one	-	Sus scrofa
6-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
6-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
6-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
6-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
6-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
6-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
6-chlorobenzo[d]isoxazol-3-ol	-	Homo sapiens
6-chlorobenzo[d]isoxazol-3-ol	-	Rattus norvegicus
6-chlorobenzo[d]isoxazol-3-ol	-	Sus scrofa
6-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
6-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
6-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione .	-	Rattus norvegicus
6-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
6-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
6-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
6-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
6-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
6-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
6-phenethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
6-phenethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
6-phenethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7,8-dibromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7,8-dibromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7,8-dibromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7,8-dichloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7,8-dichloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7,8-dichloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-bromo-8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-bromo-8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-bromo-8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-bromo-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-bromo-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-bromo-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-fluoro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-fluoro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-fluoro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
7-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
7-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
7-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	potent inhibitor	Homo sapiens
8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	potent inhibitor	Rattus norvegicus
8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	potent inhibitor	Sus scrofa
8-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-ethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-ethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-ethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-isopropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-isopropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-isopropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-phenoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-phenoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-phenoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-phenylethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-phenylethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-phenylethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-phenylpropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-phenylpropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-phenylpropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
8-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Homo sapiens
8-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Rattus norvegicus
8-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione	-	Sus scrofa
methyl 2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylate	-	Homo sapiens
methyl 2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylate	-	Rattus norvegicus
methyl 2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylate	-	Sus scrofa
quinoxaline-2,3-dione	-	Homo sapiens
quinoxaline-2,3-dione	-	Rattus norvegicus
quinoxaline-2,3-dione	-	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Sus scrofa	-
spinal cord	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
D-Ala + H2O + O2	-	Homo sapiens	pyruvate + NH3 + H2O2	-	?
D-Ala + H2O + O2	-	Rattus norvegicus	pyruvate + NH3 + H2O2	-	?
D-Ala + H2O + O2	-	Sus scrofa	pyruvate + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
DAAO	-	Homo sapiens
DAAO	-	Rattus norvegicus
DAAO	-	Sus scrofa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000043	-	at pH 8.2 and 37°C	Homo sapiens	3-hydroxyquinolin-2-one
0.00009	-	at pH 8.2 and 37°C	Rattus norvegicus	6-chlorobenzo[d]isoxazol-3-ol
0.000094	-	at pH 8.2 and 37°C	Rattus norvegicus	3-hydroxyquinolin-2-one
0.0001	-	at pH 8.2 and 37°C	Sus scrofa	3-hydroxyquinolin-2-one
0.00011	-	at pH 8.2 and 37°C	Homo sapiens	6-chlorobenzo[d]isoxazol-3-ol
0.00014	-	at pH 8.2 and 37°C	Rattus norvegicus	8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00015	-	at pH 8.2 and 37°C	Rattus norvegicus	7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00015	-	at pH 8.2 and 37°C	Sus scrofa	7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00018	-	at pH 8.2 and 37°C	Sus scrofa	8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00021	-	at pH 8.2 and 37°C	Sus scrofa	6-chlorobenzo[d]isoxazol-3-ol
0.00021	-	at pH 8.2 and 37°C	Homo sapiens	8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00022	-	at pH 8.2 and 37°C	Sus scrofa	8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00023	-	at pH 8.2 and 37°C	Homo sapiens	8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00024	-	at pH 8.2 and 37°C	Sus scrofa	8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00026	-	at pH 8.2 and 37°C	Sus scrofa	7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00034	-	at pH 8.2 and 37°C	Homo sapiens	7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0004	-	at pH 8.2 and 37°C	Sus scrofa	7-bromo-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00046	-	at pH 8.2 and 37°C	Sus scrofa	7-fluoro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00048	-	at pH 8.2 and 37°C	Sus scrofa	7-bromo-8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00052	-	at pH 8.2 and 37°C	Sus scrofa	8-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00053	-	at pH 8.2 and 37°C	Sus scrofa	7,8-dibromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00063	-	at pH 8.2 and 37°C	Sus scrofa	8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00065	-	at pH 8.2 and 37°C	Sus scrofa	7,8-dichloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00113	-	at pH 8.2 and 37°C	Homo sapiens	7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00138	-	at pH 8.2 and 37°C	Homo sapiens	8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00224	-	at pH 8.2 and 37°C	Rattus norvegicus	8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0024	-	at pH 8.2 and 37°C	Sus scrofa	8-ethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00416	-	at pH 8.2 and 37°C	Rattus norvegicus	7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0057	-	at pH 8.2 and 37°C	Sus scrofa	1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0067	-	at pH 8.2 and 37°C	Sus scrofa	7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00799	-	at pH 8.2 and 37°C	Rattus norvegicus	8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0124	-	at pH 8.2 and 37°C	Sus scrofa	7-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0177	-	at pH 8.2 and 37°C	Sus scrofa	6-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0203	-	at pH 8.2 and 37°C	Sus scrofa	6-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0229	-	at pH 8.2 and 37°C	Sus scrofa	7-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0336	-	at pH 8.2 and 37°C	Sus scrofa	quinoxaline-2,3-dione
0.0367	-	at pH 8.2 and 37°C	Sus scrofa	7-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0857	-	at pH 8.2 and 37°C	Sus scrofa	8-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.1	-	at pH 8.2 and 37°C	Sus scrofa	6-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.1	-	at pH 8.2 and 37°C	Sus scrofa	6-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.1	-	at pH 8.2 and 37°C	Sus scrofa	8-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.1	-	at pH 8.2 and 37°C	Sus scrofa	8-isopropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.3	-	at pH 8.2 and 37°C	Sus scrofa	8-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.3	-	at pH 8.2 and 37°C	Sus scrofa	8-phenylethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.3	-	at pH 8.2 and 37°C	Sus scrofa	8-phenylpropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.3	-	at pH 8.2 and 37°C	Sus scrofa	6-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.3	-	at pH 8.2 and 37°C	Sus scrofa	6-phenethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
1	-	at pH 8.2 and 37°C	Sus scrofa	methyl 2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylate
1	-	at pH 8.2 and 37°C	Sus scrofa	2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylic acid
1	-	at pH 8.2 and 37°C	Sus scrofa	8-phenoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione