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Literature summary for 1.4.3.3 extracted from

  • Pollegioni, L.; Molla, G.
    New biotech applications from evolved D-amino acid oxidases (2011), Trends Biotechnol., 29, 276-283.
    View publication on PubMed

Application

Application Comment Organism
industry the enzyme is used as a biocatalyst for resolving racemic amino acid mixtures, as a tool for biosensing, and as a mechanism of herbicide resistance Rhodotorula toruloides
industry the enzyme is used as a biocatalyst for resolving racemic amino acid mixtures, as a tool for biosensing, and as a mechanism of herbicide resistance Glutamicibacter protophormiae
medicine the enzyme is a potential valuable tool for cancer treatments that exploit the production of H2O2 Homo sapiens
medicine the enzyme is a potential valuable tool for cancer treatments that exploit the production of H2O2 Rhodotorula toruloides

Protein Variants

Protein Variants Comment Organism
S19G/S120P/Q144R/K321M/A345V the mutant possesses a 10fold lower KM,O2, thus resulting in dramatically increased activity at low O2 concentrations Rhodotorula toruloides

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxyquinolin-2-(1H)-one
-
Homo sapiens
5-methylpyrazole-3-carboxylic acid
-
Homo sapiens
6-chlorobenzo[d]isoxazol-3-ol
-
Homo sapiens
benzoate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-amino acid + H2O + O2 Glutamicibacter protophormiae
-
a 2-oxo carboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2 Homo sapiens
-
2-oxocarboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2 [Candida] boidinii
-
2-oxocarboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2 Rhodotorula toruloides
-
2-oxocarboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2 Trigonopsis variabilis
-
2-oxocarboxylate + NH3 + H2O2
-
ir

Organism

Organism UniProt Comment Textmining
Glutamicibacter protophormiae
-
-
-
Homo sapiens
-
-
-
Rhodotorula toruloides
-
-
-
Trigonopsis variabilis
-
-
-
[Candida] boidinii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cephalosporin C + H2O + O2
-
Rhodotorula toruloides 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
ir
D-alanine + H2O + O2
-
Rhodotorula toruloides pyruvate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2
-
Glutamicibacter protophormiae a 2-oxo carboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2
-
Homo sapiens 2-oxocarboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2
-
[Candida] boidinii 2-oxocarboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2
-
Rhodotorula toruloides 2-oxocarboxylate + NH3 + H2O2
-
ir
D-amino acid + H2O + O2
-
Trigonopsis variabilis 2-oxocarboxylate + NH3 + H2O2
-
ir
D-glufosinate + H2O + O2
-
Rhodotorula toruloides ?
-
ir
D-methionine + H2O + O2
-
Glutamicibacter protophormiae 2-oxo-4-methylthiobutyric acid + NH3 + H2O2
-
ir
DL-2-naphthyl-alanine + H2O + O2
-
Rhodotorula toruloides L-2-naphthyl-alanine + 2-naphthylpyruvic acid + NH3 + H2O2
-
ir

Synonyms

Synonyms Comment Organism
D-amino acid oxidase
-
Homo sapiens
D-amino acid oxidase
-
[Candida] boidinii
D-amino acid oxidase
-
Rhodotorula toruloides
D-amino acid oxidase
-
Glutamicibacter protophormiae
D-amino acid oxidase
-
Trigonopsis variabilis
DAAO
-
Homo sapiens
DAAO
-
[Candida] boidinii
DAAO
-
Rhodotorula toruloides
DAAO
-
Glutamicibacter protophormiae
DAAO
-
Trigonopsis variabilis

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
FAD
-
[Candida] boidinii
FAD
-
Rhodotorula toruloides
FAD
-
Glutamicibacter protophormiae
FAD
-
Trigonopsis variabilis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000004
-
pH and temperature not specified in the publication Homo sapiens 3-hydroxyquinolin-2-(1H)-one
0.00019
-
pH and temperature not specified in the publication Homo sapiens 6-chlorobenzo[d]isoxazol-3-ol
0.00091
-
pH and temperature not specified in the publication Homo sapiens 5-methylpyrazole-3-carboxylic acid
0.016
-
pH and temperature not specified in the publication Homo sapiens benzoate

Expression

Organism Comment Expression
Homo sapiens enzyme activity and expression are increased in schizophrenia patients up