Application | Comment | Organism |
---|---|---|
industry | the enzyme is used as a biocatalyst for resolving racemic amino acid mixtures, as a tool for biosensing, and as a mechanism of herbicide resistance | Rhodotorula toruloides |
industry | the enzyme is used as a biocatalyst for resolving racemic amino acid mixtures, as a tool for biosensing, and as a mechanism of herbicide resistance | Glutamicibacter protophormiae |
medicine | the enzyme is a potential valuable tool for cancer treatments that exploit the production of H2O2 | Homo sapiens |
medicine | the enzyme is a potential valuable tool for cancer treatments that exploit the production of H2O2 | Rhodotorula toruloides |
Protein Variants | Comment | Organism |
---|---|---|
S19G/S120P/Q144R/K321M/A345V | the mutant possesses a 10fold lower KM,O2, thus resulting in dramatically increased activity at low O2 concentrations | Rhodotorula toruloides |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-hydroxyquinolin-2-(1H)-one | - |
Homo sapiens | |
5-methylpyrazole-3-carboxylic acid | - |
Homo sapiens | |
6-chlorobenzo[d]isoxazol-3-ol | - |
Homo sapiens | |
benzoate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-amino acid + H2O + O2 | Glutamicibacter protophormiae | - |
a 2-oxo carboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | Homo sapiens | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | [Candida] boidinii | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | Rhodotorula toruloides | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | Trigonopsis variabilis | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Glutamicibacter protophormiae | - |
- |
- |
Homo sapiens | - |
- |
- |
Rhodotorula toruloides | - |
- |
- |
Trigonopsis variabilis | - |
- |
- |
[Candida] boidinii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cephalosporin C + H2O + O2 | - |
Rhodotorula toruloides | 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2 | - |
ir | |
D-alanine + H2O + O2 | - |
Rhodotorula toruloides | pyruvate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | - |
Glutamicibacter protophormiae | a 2-oxo carboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | - |
Homo sapiens | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | - |
[Candida] boidinii | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | - |
Rhodotorula toruloides | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
D-amino acid + H2O + O2 | - |
Trigonopsis variabilis | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
D-glufosinate + H2O + O2 | - |
Rhodotorula toruloides | ? | - |
ir | |
D-methionine + H2O + O2 | - |
Glutamicibacter protophormiae | 2-oxo-4-methylthiobutyric acid + NH3 + H2O2 | - |
ir | |
DL-2-naphthyl-alanine + H2O + O2 | - |
Rhodotorula toruloides | L-2-naphthyl-alanine + 2-naphthylpyruvic acid + NH3 + H2O2 | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
D-amino acid oxidase | - |
Homo sapiens |
D-amino acid oxidase | - |
[Candida] boidinii |
D-amino acid oxidase | - |
Rhodotorula toruloides |
D-amino acid oxidase | - |
Glutamicibacter protophormiae |
D-amino acid oxidase | - |
Trigonopsis variabilis |
DAAO | - |
Homo sapiens |
DAAO | - |
[Candida] boidinii |
DAAO | - |
Rhodotorula toruloides |
DAAO | - |
Glutamicibacter protophormiae |
DAAO | - |
Trigonopsis variabilis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
[Candida] boidinii | |
FAD | - |
Rhodotorula toruloides | |
FAD | - |
Glutamicibacter protophormiae | |
FAD | - |
Trigonopsis variabilis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000004 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-hydroxyquinolin-2-(1H)-one | |
0.00019 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-chlorobenzo[d]isoxazol-3-ol | |
0.00091 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-methylpyrazole-3-carboxylic acid | |
0.016 | - |
pH and temperature not specified in the publication | Homo sapiens | benzoate |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme activity and expression are increased in schizophrenia patients | up |