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Literature summary for 1.4.3.3 extracted from

  • Smith, S.M.; Uslaner, J.M.; Yao, L.; Mullins, C.M.; Surles, N.O.; Huszar, S.L.; McNaughton, C.H.; Pascarella, D.M.; Kandebo, M.; Hinchliffe, R.M.; Sparey, T.; Brandon, N.J.; Jones, B.; Venkatraman, S.; Young, M.B.; Sachs, N.; Jacobson, M.A.; Hutson, P.H.
    The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine (2009), J. Pharmacol. Exp. Ther., 328, 921-930.
    View publication on PubMed
Search for more literature for 1.4.3.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells Homo sapiens
expression in CHO cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
4H-thieno [3,2-b]pyrrole-5-carboxylic acid i.e. compound 8, a moderately potent inhibitor of human DAAO in vitro Homo sapiens
4H-thieno [3,2-b]pyrrole-5-carboxylic acid i.e. compound 8, a moderately potent inhibitor of rat DAAO in vitro, inhibits DAAO activity in kideny by 96% and in brain by 80% resulting in a significant elevation in both plasma and cerebrospinal fluid D-serine concentration. Compound 8 fails to significantly influence amphetamine-induced psychomotor activity, nucleus accumbens dopamine release, or a dizocilpine maleate-induced deficit in novel object recognition in rats Rattus norvegicus
5-methyl-1H-pyrazole-3-carboxylic acid
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alanine + H2O + O2 Homo sapiens
-
 pyruvate + NH3 + H2O2
-
 ?
D-alanine + H2O + O2 Rattus norvegicus
-
 pyruvate + NH3 + H2O2
-
 ?
D-serine + H2O + O2 Homo sapiens
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-serine + H2O + O2 Rattus norvegicus high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cerebellum and cortex Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
D-alanine + H2O + O2
-
 Rattus norvegicus pyruvate + NH3 + H2O2
-
 ?
D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-serine + H2O + O2
-
 Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-serine + H2O + O2 high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
DAAO
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
 assay at Homo sapiens
8.2
-
 assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000114
-
-
 Rattus norvegicus 4H-thieno [3,2-b]pyrrole-5-carboxylic acid
0.000145
-
-
 Homo sapiens 4H-thieno [3,2-b]pyrrole-5-carboxylic acid