Activating Compound | Comment | Organism | Structure |
---|---|---|---|
pLG72 | i.e. DAOA or D-amino acid oxidase activator, interacts with and activates the enzyme | Rattus norvegicus | |
pLG72 | i.e. DAOA or D-amino acid oxidase activator, interacts with and activates the enzyme, genotyping in healthy persons and schizophrenia patients, overview | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a drug target in schizophrenia | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4H-thieno[3,2-b] pyrrole-5-carboxylic acid | i.e. compound 8, very specific inhibitor of DAAO | Homo sapiens | |
4H-thieno[3,2-b] pyrrole-5-carboxylic acid | i.e. compound 8, very specific inhibitor of DAAO. Compound 8 at 200 mg/kg body weight inhibits rat kidney and cerebellar DAAO by approximately 96% and 80%, respectively. Effects after in vivo application, overview | Rattus norvegicus | |
5-methylpyrazole-3-carboxylic acid | i.e. AS057278 | Homo sapiens | |
5-methylpyrazole-3-carboxylic acid | i.e. AS057278 | Rattus norvegicus | |
6-chlorobenzo[d]isoxazol-3-ol | competitive | Homo sapiens | |
6-chlorobenzo[d]isoxazol-3-ol | competitive | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | Homo sapiens | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | Rattus norvegicus | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Homo sapiens | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Rattus norvegicus | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
cerebellum | - |
Rattus norvegicus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | - |
Homo sapiens | pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | - |
Rattus norvegicus | pyruvate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Rattus norvegicus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-amino acid oxidase | - |
Homo sapiens |
D-amino acid oxidase | - |
Rattus norvegicus |
DAAO | - |
Homo sapiens |
DAAO | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000145 | - |
- |
Homo sapiens | 4H-thieno[3,2-b] pyrrole-5-carboxylic acid | |
0.000145 | - |
- |
Rattus norvegicus | 4H-thieno[3,2-b] pyrrole-5-carboxylic acid | |
0.000188 | - |
- |
Homo sapiens | 6-chlorobenzo[d]isoxazol-3-ol | |
0.000188 | - |
- |
Rattus norvegicus | 6-chlorobenzo[d]isoxazol-3-ol | |
0.000901 | - |
- |
Homo sapiens | 5-methylpyrazole-3-carboxylic acid | |
0.000901 | - |
- |
Rattus norvegicus | 5-methylpyrazole-3-carboxylic acid |