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Literature summary for 1.4.3.22 extracted from

  • Costa, M.T.; Rotilio, G.; Agro, A.F.; Vallogini, M.P.; Mondovi, B.
    On the active site of diamine oxidase: kinetic studies (1971), Arch. Biochem. Biophys., 147, 8-13.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
m-phenylenediamine competitive vs. cadaverine Sus scrofa
additional information no substrate inhibition with monoamines; substrate inhibition with diamines Sus scrofa
o-phenyldiamine
-
Sus scrofa
o-phenylenediamine competitive vs. cadaverine Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
histamine at pH 7.4 Sus scrofa
0.083
-
histamine at pH 6.3 Sus scrofa
0.17
-
histamine at pH 8.5 Sus scrofa
0.73
-
cadaverine at pH 7.4 Sus scrofa
0.83
-
cadaverine at pH 8.5 Sus scrofa
1.3
-
cadaverine at pH 6.3 Sus scrofa
3
-
Butylamine at pH 8.5 Sus scrofa
4
-
Butylamine at pH 6.3 Sus scrofa
5
-
Butylamine at pH 7.4 Sus scrofa
6.5
-
lysine methylester at pH 7.4 Sus scrofa
6.6
-
Propylamine at pH 7.4 Sus scrofa
66
-
ethylamine at pH 7.4 Sus scrofa
66
-
ethylenediamine at pH 7.4 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butylamine + H2O + O2
-
Sus scrofa butanal + NH3 + H2O2
-
r
ethylamine + H2O + O2
-
Sus scrofa acetaldehyde + NH3 + H2O2
-
r
ethylenediamine + H2O + O2
-
Sus scrofa ?
-
r
histamine + H2O + O2
-
Sus scrofa (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
?
L-lysine methyl ester + H2O + O2
-
Sus scrofa ?
-
?
propylamine + H2O + O2
-
Sus scrofa propanal + NH3 + H2O2
-
r
RCH2NH2 + H2O + O2
-
Sus scrofa RCHO + NH3 + H2O2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
10
-
o-phenyldiamine
-
Sus scrofa
10
-
m-phenyldiamine
-
Sus scrofa