Literature summary for 1.4.3.21 extracted from

Lee, Y.; Ling, K.Q.; Lu, X.; Silverman, R.B.; Shepard, E.M.; Dooley, D.M.; Sayre, L.M.
3-Pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases (2002), J. Am. Chem. Soc., 124, 12135-12143.

Search for more literature for 1.4.3.21

Inhibitors

Inhibitors	Comment	Organism	Structure
3-(2-naphthyl)-3-pyrroline	0.2 mM, inactivation of BPAO by 3-aryl-3-pyrrolines	Bos taurus
3-(4-methoxy-3-nitrophenyl)-3-pyrroline	0.015 mM, inactivation of BPAO by 3-aryl-3-pyrrolines	Bos taurus
3-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole hydrochloride	0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines	Bos taurus
3-biphenyl-4-yl-2,5-dihydro-1H-pyrrole hydrochloride	0.1 mM, inactivation of BPAO by 3-aryl-3-pyrrolines	Bos taurus
3-naphthalen-1-yl-2,5-dihydro-1H-pyrrole hydrochloride	0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines	Bos taurus
3-phenyl-3-pyrroline	0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines	Bos taurus
3-pyrroline	-	Bos taurus
4-(2,5-dihydro-1H-pyrrol-3-yl)-N,N-dimethylaniline hydrochloride	0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines	Bos taurus
additional information	3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases	Bos taurus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
copper	copper-containing amine oxidase	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Bos taurus	-
plasma	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2	-	Bos taurus	? + H2O2 + NH3	-	?

Synonyms

Synonyms	Comment	Organism
bovine plasma amine oxidase	-	Bos taurus
BPAO	-	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
2,4,5-trihydroxyphenylalanine quinone	-	Bos taurus

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Release 2023.1 (January 2023)