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Literature summary for 1.4.3.2 extracted from

  • Izidoro, L.F.; Sobrinho, J.C.; Mendes, M.M.; Costa, T.R.; Grabner, A.N.; Rodrigues, V.M.; da Silva, S.L.; Zanchi, F.B.; Zuliani, J.P.; Fernandes, C.F.; Calderon, L.A.; Stabeli, R.G.; Soares, A.M.
    Snake venom L-amino acid oxidases trends in pharmacology and biochemistry (2014), BioMed Res. Int., 2014, 196754 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.023
-
L-Trp pH and temperature not specified in the publication Gloydius ussuriensis
0.042
-
L-Phe pH and temperature not specified in the publication Gloydius ussuriensis
0.05
-
L-Phe pH and temperature not specified in the publication Calloselasma rhodostoma
0.051
-
L-Phe pH and temperature not specified in the publication Naja oxiana
0.058
-
L-Phe pH and temperature not specified in the publication Vipera berus berus
0.08
-
L-Trp pH and temperature not specified in the publication Calloselasma rhodostoma
0.1
-
L-Phe pH and temperature not specified in the publication Ophiophagus hannah
0.1
-
L-Trp pH and temperature not specified in the publication Ophiophagus hannah
0.11
-
L-Leu pH and temperature not specified in the publication Gloydius ussuriensis
0.147
-
L-Trp pH and temperature not specified in the publication Naja oxiana
0.17
-
L-Trp pH and temperature not specified in the publication Macrovipera lebetina
0.2
-
L-Leu pH and temperature not specified in the publication Ophiophagus hannah
0.24
-
L-Met pH and temperature not specified in the publication Calloselasma rhodostoma
0.27
-
L-Trp pH and temperature not specified in the publication Bungarus fasciatus
0.286
-
L-Met pH and temperature not specified in the publication Vipera berus berus
0.361
-
L-Leu pH and temperature not specified in the publication Vipera berus berus
0.4
-
L-Leu pH and temperature not specified in the publication Macrovipera lebetina
0.63
-
L-Leu pH and temperature not specified in the publication Calloselasma rhodostoma
0.63
-
L-Met pH and temperature not specified in the publication Ophiophagus hannah
0.65
-
L-Met pH and temperature not specified in the publication Macrovipera lebetina
0.75
-
L-Leu pH and temperature not specified in the publication Naja oxiana
0.88
-
L-Met pH and temperature not specified in the publication Gloydius ussuriensis
0.885
-
L-Met pH and temperature not specified in the publication Naja oxiana
0.97
-
L-Leu pH and temperature not specified in the publication Lachesis muta
9.23
-
L-Leu pH and temperature not specified in the publication Crotalus durissus cumanensis
15.03
-
L-Met pH and temperature not specified in the publication Bungarus fasciatus
60.69
-
L-Leu pH and temperature not specified in the publication Bungarus fasciatus
84.08
-
L-Phe pH and temperature not specified in the publication Bungarus fasciatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Arg + H2O + O2 Macrovipera lebetina
-
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2 Bungarus fasciatus
-
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2 Bungarus caeruleus
-
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2 Vipera berus berus
-
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2 Aplysia punctata
-
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Asp + H2O + O2 Bungarus fasciatus
-
oxaloacetate + NH3 + H2O2
-
?
L-Glu + H2O + O2 Bungarus fasciatus
-
2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2 Bungarus caeruleus
-
2-oxoglutarate + NH3 + H2O2
-
?
L-His + H2O + O2 Ophiophagus hannah
-
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2 Macrovipera lebetina
-
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2 Bothrops pirajai
-
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2 Vipera berus berus
-
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Bothrops atrox
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Bothrops jararaca
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Ophiophagus hannah
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Macrovipera lebetina
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Bungarus fasciatus
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Bothrops pirajai
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Bungarus caeruleus
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Bothrops pauloensis
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2 Vipera berus berus
-
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Calloselasma rhodostoma
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bothrops atrox
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Daboia russelii
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bothrops jararaca
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Ophiophagus hannah
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Lachesis muta
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Naja oxiana
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Macrovipera lebetina
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bungarus fasciatus
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bothrops alternatus
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bothrops pirajai
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Gloydius ussuriensis
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bungarus caeruleus
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bothrops pauloensis
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Crotalus durissus cumanensis
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bothrops leucurus
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Vipera berus berus
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Lys + H2O + O2 Ophiophagus hannah
-
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2 Aplysia punctata
-
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
?
L-Met + H2O + O2 Calloselasma rhodostoma
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Bothrops atrox
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Ophiophagus hannah
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Naja oxiana
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Macrovipera lebetina
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Bungarus fasciatus
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Bothrops alternatus
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Bothrops pirajai
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Gloydius ussuriensis
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Bungarus caeruleus
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Bothrops pauloensis
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Vipera berus berus
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Calloselasma rhodostoma
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bothrops atrox
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bothrops jararaca
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Ophiophagus hannah
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Naja oxiana
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Macrovipera lebetina
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bungarus fasciatus
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bothrops alternatus
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bothrops pirajai
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Gloydius ussuriensis
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bungarus caeruleus
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bothrops pauloensis
-
phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Vipera berus berus
-
phenylpyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Calloselasma rhodostoma
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Bothrops atrox
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Ophiophagus hannah
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Naja oxiana
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Macrovipera lebetina
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Bungarus fasciatus
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Bothrops pirajai
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Gloydius ussuriensis
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2 Bungarus caeruleus
-
indole-3-pyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Bothrops atrox
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Bothrops jararaca
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Bungarus fasciatus
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Bothrops alternatus
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Bothrops pirajai
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Val + H2O + O2 Bothrops pirajai
-
2-oxoisovalerate + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Aplysia punctata
-
-
-
Bothrops alternatus
-
-
-
Bothrops atrox
-
-
-
Bothrops insularis
-
-
-
Bothrops jararaca
-
-
-
Bothrops leucurus
-
-
-
Bothrops marajoensis
-
-
-
Bothrops pauloensis
-
-
-
Bothrops pirajai
-
-
-
Bungarus caeruleus
-
-
-
Bungarus fasciatus
-
-
-
Calloselasma rhodostoma
-
-
-
Crotalus durissus cumanensis
-
-
-
Daboia russelii
-
-
-
Deinagkistrodon acutus
-
-
-
Gloydius ussuriensis
-
-
-
Lachesis muta
-
-
-
Macrovipera lebetina
-
-
-
Naja oxiana
-
-
-
Ophiophagus hannah
-
-
-
Vipera berus berus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
benzamidine-Sepharose and phenyl-Sepharose column chromatography Bothrops pirajai
CM-Sepharose column chromatography, phenyl-Sepharose CL-4B column chromatography, benzamidine Sepharose and C18 RP column chromatography Bothrops pauloensis
DEAE cellulose column chromatography and Sephadex G-100 gel filtration Bungarus caeruleus
DEAE Sepharose F column chromatography and Source 30 column chromatography Deinagkistrodon acutus
G-75 gel filtration, HPLC-Shodex ES-502N 7C column chromatography, and Lentil lectin column chromatography Bothrops atrox
HPLC AP1 column chromatography and Superdex 75 gel filtration Bothrops insularis
ion-exchange column chromatography, Sephadex G-75 gel filtration and C4 reverse phase protein pack SP 5PW chromatography Gloydius ussuriensis
Mono Q and heparin column chromatography Bothrops jararaca
Protein Pack SP 5PW anion exchange chromatography and Superdex 200 gel filtration Bothrops marajoensis
Sephacryl S-200 gel filtration, Sephacryl S-300 gel filtration, and DEAE Sepharose CL-6B column chromatography Bothrops leucurus
Sephacryl S200 column chromatography Crotalus durissus cumanensis
Sephacryl S200 gel filtration and MonoQ column chromatography Lachesis muta
Sephadex G-100 gel filtration, DEAE-cellulose column chromatography, and phenyl-agarose column chromatography Vipera berus berus
Sephadex G-100 gel filtration, HPS-7 column chromatography, DEAE-cellulose DE52 column chromatography, and CM-cellulose CM52 column chromatography Macrovipera lebetina
Sephadex G-100 gel filtration, Q column chromatography, and HiTrap heparin column chromatography Ophiophagus hannah
Sephadex G-50 SF gel filtration, CM-cellulose CM52 column chromatography, and HPS-7 column chromatography Naja oxiana
Sepharose-IDA column chromatography, phenyl-Sepharose column chromatography, and Sephadex G-100 gel filtration Bothrops alternatus
Source 15Q column chromatography and Superose 12 gel filtration Aplysia punctata
SP-Sepharose column chromatography and heparin-Sepharose column chromatography Bungarus fasciatus
Superdex 75 gel filtration, Mono Q column chromatography, and heparin-Sepharose column chromatography Daboia russelii

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Calloselasma rhodostoma
-
venom
-
Bothrops atrox
-
venom
-
Bothrops marajoensis
-
venom
-
Daboia russelii
-
venom
-
Bothrops jararaca
-
venom
-
Ophiophagus hannah
-
venom
-
Lachesis muta
-
venom
-
Naja oxiana
-
venom
-
Macrovipera lebetina
-
venom
-
Deinagkistrodon acutus
-
venom
-
Bungarus fasciatus
-
venom
-
Bothrops alternatus
-
venom
-
Bothrops pirajai
-
venom
-
Gloydius ussuriensis
-
venom
-
Bungarus caeruleus
-
venom
-
Bothrops insularis
-
venom
-
Bothrops pauloensis
-
venom
-
Crotalus durissus cumanensis
-
venom
-
Bothrops leucurus
-
venom
-
Vipera berus berus
-
venom
-
Aplysia punctata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg + H2O + O2
-
Macrovipera lebetina 2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2
-
Bungarus fasciatus 2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2
-
Bungarus caeruleus 2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2
-
Vipera berus berus 2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2
-
Aplysia punctata 2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Asp + H2O + O2
-
Bungarus fasciatus oxaloacetate + NH3 + H2O2
-
?
L-Glu + H2O + O2
-
Bungarus fasciatus 2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2
-
Bungarus caeruleus 2-oxoglutarate + NH3 + H2O2
-
?
L-His + H2O + O2
-
Ophiophagus hannah 2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2
-
Macrovipera lebetina 2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2
-
Bothrops pirajai 2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2
-
Vipera berus berus 2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Bothrops atrox 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Bothrops jararaca 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Ophiophagus hannah 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Macrovipera lebetina 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Bungarus fasciatus 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Bothrops pirajai 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Bungarus caeruleus 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Bothrops pauloensis 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Ile + H2O + O2
-
Vipera berus berus 3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Calloselasma rhodostoma 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bothrops atrox 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Daboia russelii 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bothrops jararaca 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Ophiophagus hannah 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Lachesis muta 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Naja oxiana 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Macrovipera lebetina 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bungarus fasciatus 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bothrops alternatus 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bothrops pirajai 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Gloydius ussuriensis 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bungarus caeruleus 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bothrops pauloensis 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Crotalus durissus cumanensis 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bothrops leucurus 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Vipera berus berus 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Ophiophagus hannah 6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Aplysia punctata 6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Calloselasma rhodostoma 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Bothrops atrox 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Ophiophagus hannah 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Naja oxiana 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Macrovipera lebetina 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Bungarus fasciatus 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Bothrops alternatus 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Bothrops pirajai 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Gloydius ussuriensis 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Bungarus caeruleus 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Bothrops pauloensis 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Vipera berus berus 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Calloselasma rhodostoma phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Bothrops atrox phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Bothrops jararaca phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Ophiophagus hannah phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Naja oxiana phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Macrovipera lebetina phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Bungarus fasciatus phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Bothrops alternatus phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Bothrops pirajai phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Gloydius ussuriensis phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Bungarus caeruleus phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Bothrops pauloensis phenylpyruvate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Vipera berus berus phenylpyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Calloselasma rhodostoma indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Bothrops atrox indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Ophiophagus hannah indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Naja oxiana indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Macrovipera lebetina indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Bungarus fasciatus indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Bothrops pirajai indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Gloydius ussuriensis indole-3-pyruvate + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Bungarus caeruleus indole-3-pyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Bothrops atrox 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Bothrops jararaca 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Bungarus fasciatus 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Bothrops alternatus 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Bothrops pirajai 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Val + H2O + O2
-
Bothrops pirajai 2-oxoisovalerate + NH3 + H2O2
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 28000, SDS-PAGE Deinagkistrodon acutus
homodimer 2 * 55000, SDS-PAGE Bungarus fasciatus
homodimer 2 * 55000, SDS-PAGE Bungarus caeruleus
homodimer 2 * 55000, SDS-PAGE Crotalus durissus cumanensis
homodimer 2 * 60000, SDS-PAGE Lachesis muta
homodimer 2 * 60000, SDS-PAGE Aplysia punctata
homodimer 2 * 64000, SDS-PAGE Ophiophagus hannah
homodimer 2 * 66000, SDS-PAGE Macrovipera lebetina
homodimer 2 * 66000, SDS-PAGE Bothrops alternatus
homodimer 2 * 66000, SDS-PAGE Bothrops pirajai
homodimer 2 * 72000, SDS-PAGE Bothrops marajoensis
homodimer 2 * 57000, SDS-PAGE Naja oxiana
homodimer 2 * 57000, SDS-PAGE Bothrops leucurus
homodimer 2 * 59000, SDS-PAGE Vipera berus berus
homodimer 2 * 67000, SDS-PAGE Bothrops atrox
homodimer 2 * 68000, SDS-PAGE Bothrops insularis
homodimer 2 * 65000, SDS-PAGE Gloydius ussuriensis
homodimer 2 * 65000, SDS-PAGE Bothrops pauloensis
homodimer 2 * 38200, SDS-PAGE Bothrops jararaca
homodimer 2 * 63600, SDS-PAGE Daboia russelii

Synonyms

Synonyms Comment Organism
ACTX-8
-
Deinagkistrodon acutus
LAAO
-
Calloselasma rhodostoma
LAAO
-
Bothrops atrox
LAAO
-
Bothrops marajoensis
LAAO
-
Bothrops jararaca
LAAO
-
Ophiophagus hannah
LAAO
-
Lachesis muta
LAAO
-
Naja oxiana
LAAO
-
Macrovipera lebetina
LAAO
-
Deinagkistrodon acutus
LAAO
-
Bungarus fasciatus
LAAO
-
Gloydius ussuriensis
LAAO
-
Bothrops pauloensis
LAAO
-
Crotalus durissus cumanensis
LAAO
-
Bothrops leucurus
LAAO
-
Vipera berus berus
LAAO
-
Aplysia punctata
LAAO-I
-
Bothrops alternatus
LAAOI
-
Bothrops pirajai
LAO
-
Daboia russelii
LAO
-
Bungarus caeruleus
LAO
-
Bothrops insularis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.72
-
L-Phe pH and temperature not specified in the publication Calloselasma rhodostoma
0.88
-
L-Trp pH and temperature not specified in the publication Calloselasma rhodostoma
1.65
-
L-Met pH and temperature not specified in the publication Calloselasma rhodostoma
1.8
-
L-Leu pH and temperature not specified in the publication Crotalus durissus cumanensis
3.3
-
L-Leu pH and temperature not specified in the publication Calloselasma rhodostoma
6.58
-
L-Trp pH and temperature not specified in the publication Gloydius ussuriensis
17.18
-
L-Phe pH and temperature not specified in the publication Naja oxiana
18.04
-
L-Trp pH and temperature not specified in the publication Naja oxiana
24.13
-
L-Met pH and temperature not specified in the publication Gloydius ussuriensis
28.5
-
L-Phe pH and temperature not specified in the publication Vipera berus berus
32.1
-
L-Trp pH and temperature not specified in the publication Ophiophagus hannah
42.65
-
L-Trp pH and temperature not specified in the publication Macrovipera lebetina
47.98
-
L-Leu pH and temperature not specified in the publication Naja oxiana
48.22
-
L-Leu pH and temperature not specified in the publication Gloydius ussuriensis
48.23
-
L-Phe pH and temperature not specified in the publication Gloydius ussuriensis
52
-
L-Leu pH and temperature not specified in the publication Macrovipera lebetina
54.1
-
L-Phe pH and temperature not specified in the publication Ophiophagus hannah
65.6
-
L-Met pH and temperature not specified in the publication Ophiophagus hannah
66.26
-
L-Met pH and temperature not specified in the publication Naja oxiana
74.2
-
L-Met pH and temperature not specified in the publication Vipera berus berus
75.16
-
L-Leu pH and temperature not specified in the publication Vipera berus berus
80.3
-
L-Met pH and temperature not specified in the publication Macrovipera lebetina
96.2
-
L-Leu pH and temperature not specified in the publication Ophiophagus hannah
98.82
-
L-Trp pH and temperature not specified in the publication Bungarus fasciatus
142.62
-
L-Phe pH and temperature not specified in the publication Bungarus fasciatus
589.93
-
L-Met pH and temperature not specified in the publication Bungarus fasciatus
1025.05
-
L-Leu pH and temperature not specified in the publication Bungarus fasciatus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Calloselasma rhodostoma
FAD
-
Bothrops atrox
FAD
-
Bothrops marajoensis
FAD
-
Daboia russelii
FAD
-
Bothrops jararaca
FAD
-
Ophiophagus hannah
FAD
-
Lachesis muta
FAD
-
Naja oxiana
FAD
-
Macrovipera lebetina
FAD
-
Deinagkistrodon acutus
FAD
-
Bungarus fasciatus
FAD
-
Bothrops alternatus
FAD
-
Bothrops pirajai
FAD
-
Gloydius ussuriensis
FAD
-
Bungarus caeruleus
FAD
-
Bothrops insularis
FAD
-
Bothrops pauloensis
FAD
-
Crotalus durissus cumanensis
FAD
-
Bothrops leucurus
FAD
-
Vipera berus berus
FAD
-
Aplysia punctata

pI Value

Organism Comment pI Value Maximum pI Value
Bothrops atrox isoelectric focusing
-
4.4
Macrovipera lebetina isoelectric focusing
-
4.5
Aplysia punctata isoelectric focusing
-
4.6
Vipera berus berus isoelectric focusing
-
4.8
Bothrops pirajai isoelectric focusing
-
4.9
Bothrops alternatus isoelectric focusing
-
5.4
Lachesis muta isoelectric focusing
-
6.3
Bothrops pauloensis isoelectric focusing
-
6.3
Naja oxiana isoelectric focusing
-
8
Crotalus durissus cumanensis isoelectric focusing
-
8
Deinagkistrodon acutus isoelectric focusing
-
8.2

General Information

General Information Comment Organism
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Calloselasma rhodostoma
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops atrox
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops marajoensis
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Daboia russelii
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops jararaca
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Ophiophagus hannah
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Lachesis muta
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Naja oxiana
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Macrovipera lebetina
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Deinagkistrodon acutus
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bungarus fasciatus
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops alternatus
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops pirajai
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Gloydius ussuriensis
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bungarus caeruleus
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops insularis
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops pauloensis
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Bothrops leucurus
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Vipera berus berus
physiological function the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects Aplysia punctata