Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.2 extracted from

  • Mitra, J.; Bhattacharyya, D.
    Irreversible inactivation of snake venom L-amino acid oxidase by covalent modification during catalysis of l-propargylglycine (2013), FEBS open bio, 3, 135-143.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.2

Inhibitors

Inhibitors Comment Organism Structure
L-propargylglycine irreversible inhibition in a dose- and time-dependent manner Crotalus adamanteus
L-propargylglycine irreversible inhibition in a dose- and time-dependent manner Crotalus atrox

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03601
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox
0.03782
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
7.95
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
11.78
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox

Organism

Organism UniProt Comment Textmining
Crotalus adamanteus
-
-
-
Crotalus atrox
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Crotalus adamanteus
-
venom
-
 Crotalus atrox
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + H2O + O2
-
 Crotalus adamanteus phenylpyruvate + NH3 + H2O2
-
 ?
L-phenylalanine + H2O + O2
-
 Crotalus atrox phenylpyruvate + NH3 + H2O2
-
 ?
L-propargylglycine + O2 the substrate L-propargylglycine competes with the substrate L-Phe during inactivation of the enzyme Crotalus adamanteus 3-amino-5-methylene-5H-furan-2-one + H2O2
-
 ?
L-propargylglycine + O2 the substrate L-propargylglycine competes with the substrate L-Phe during inactivation of the enzyme Crotalus atrox 3-amino-5-methylene-5H-furan-2-one + H2O2
-
 ?
additional information glycine is not oxidized by the enzyme Crotalus adamanteus ?
-
 ?
additional information glycine is not oxidized by the enzyme Crotalus atrox ?
-
 ?

Synonyms

Synonyms Comment Organism
L-amino acid oxidase
-
 Crotalus adamanteus
L-amino acid oxidase
-
 Crotalus atrox
LAAO
-
 Crotalus adamanteus
LAAO
-
 Crotalus atrox

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.27
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
6.78
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox
7.75
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox
9.62
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Crotalus adamanteus
FAD
-
 Crotalus atrox

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.49
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
9.69
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox