Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Gd3+ | inhibits 17% at 10 mM | Gloydius ussuriensis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.1 | - |
L-Leu | pH 4.7, 37°C | Gloydius ussuriensis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Gloydius ussuriensis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates | Gloydius ussuriensis | |
Ce3+ | activates | Gloydius ussuriensis | |
Co2+ | activates | Gloydius ussuriensis | |
Mg2+ | activates | Gloydius ussuriensis | |
Mn2+ | activates | Gloydius ussuriensis | |
Nd3+ | activates | Gloydius ussuriensis | |
Tb3+ | activates | Gloydius ussuriensis | |
Zn2+ | Akbu-LAAO contains four Zn2þ per dimer, that are unessential for the hydrolytic activity of the enzyme. The apoenzyme shows 61% of maximal activity. The zinc ions probably help maintain the structural integrity of the enzyme | Gloydius ussuriensis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
2 * 65000, SDS-PAGE | Gloydius ussuriensis |
124400 | - |
gel filtration | Gloydius ussuriensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Leu + H2O + O2 | Gloydius ussuriensis | - |
2-oxo-4-methylvaleric acid + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gloydius ussuriensis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native extracellular enzyme 11.2fold from venom by anion exchange chromatography and 3 steps of gel filtration, one of which is HPLC | Gloydius ussuriensis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Gloydius ussuriensis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
9 | - |
purified native enzyme, pH 4.7, 37°C | Gloydius ussuriensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Leu + H2O + O2 | - |
Gloydius ussuriensis | 2-oxo-4-methylvaleric acid + NH3 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 65000, SDS-PAGE | Gloydius ussuriensis |
Synonyms | Comment | Organism |
---|---|---|
Akbu-LAAO | - |
Gloydius ussuriensis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Gloydius ussuriensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.7 | - |
first optimum | Gloydius ussuriensis |
8.5 | - |
second optimum | Gloydius ussuriensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Gloydius ussuriensis |
General Information | Comment | Organism |
---|---|---|
physiological function | Akbu-LAAO shows apparent anti-aggregation effects on human and rabbit platelets and exhibits a strong bacteriostasis effect on Staphylococcus aureus, 18fold that of cephalosporin C | Gloydius ussuriensis |