Literature summary for 1.4.3.13 extracted from

van Boxtel, A.L.; Kamstra, J.H.; Fluitsma, D.M.; Legler, J.
Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity (2010), Toxicol. Appl. Pharmacol., 244, 156-161.

Search for more literature for 1.4.3.13

Inhibitors

Inhibitors	Comment	Organism	Structure
beta-aminopropionitrile	-	Danio rerio
Disulfiram	a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview	Danio rerio
thiram	a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview	Danio rerio

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cu2+	dependent on	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Danio rerio	-

Synonyms

Synonyms	Comment	Organism
LOX	-	Danio rerio
lysyl oxidase	-	Danio rerio

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.2	-	assay at	Danio rerio

General Information

General Information	Comment	Organism
additional information	partial knockdown of three LOX genes, lox,loxl1 and loxl5b, sensitizes the developing embryo to dithiocarbamate exposure	Danio rerio

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Release 2023.1 (January 2023)