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Literature summary for 1.4.3.13 extracted from

  • Shieh, T.M.; Tu, H.F.; Ku, T.H.; Chang, S.S.; Chang, K.W.; Liu, C.J.
    Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers (2009), J. Oral Pathol. Med., 38, 109-113.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
LOX genotyping of Asian non-areca nut chewers and arec nut chewers of different ages, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
R158Q naturally occuring mutation, G to A polymorphism at nucleotide 473, causes oral submucous fibrosis and is associated to chewing of areca nuts, genotyping, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ activates, dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oral cavity
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
LOX
-
Homo sapiens
lysyl oxidase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction association between enzyme polymorphisms and oral submucous fibrosis in older male areca chewers Homo sapiens
physiological function LOX is a copper-activated enzyme critical for collagen cross-linking and organization of extracellular matrix Homo sapiens