Literature summary for 1.4.3.13 extracted from

Postovit, L.M.; Abbott, D.E.; Payne, S.L.; Wheaton, W.W.; Margaryan, N.V.; Sullivan, R.; Jansen, M.K.; Csiszar, K.; Hendrix, M.J.; Kirschmann, D.A.
Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration (2008), J. Cell. Biochem., 103, 1369-1378.

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Activating Compound

Activating Compound	Comment	Organism	Structure
hypoxia inducible factor-1	hypoxia-induced LOX expression is partially mediated by hypoxia inducible factor-1	Homo sapiens
additional information	hypoxia/reoxygenation drives poorly invasive breast cancer cells toward a more aggressive phenotype by up-regulating LOX expression and catalytic activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
beta-aminopropionitrile	0.1-0.3 mM, specific inhibitor	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cu2+	dependent	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
32000	-	mature LOX, SDS-PAGE	Homo sapiens
50000	-	immature proLOX, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
T-47D cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dichlorodihydrofluorescein diacetate + O2 + H2O	-	Homo sapiens	? + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
LOX	-	Homo sapiens
lysyl oxidase	-	Homo sapiens

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Release 2023.1 (January 2023)