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Literature summary for 1.4.3.13 extracted from

  • Hornstra, I.K.; Birge, S.; Starcher, B.; Bailey, A.J.; Mecham, R.P.; Shapiro, S.D.
    Lysyl oxidase is required for vascular and diaphragmatic development in mice (2003), J. Biol. Chem., 278, 14387-14393.
    View publication on PubMed
Search for more literature for 1.4.3.13

Protein Variants

Protein Variants Comment Organism
additional information construction of a deletion mutant by targeted mutagenesis, the mutant mice lacking the enzyme activity dies soon after parturition exhibiting cardivascular instability with ruptured arterial aneurysms and diaphragmatic rupture due to fragmented elastic fiber architecture in the aorta, overview, the homozygous mutants show about 60% reduced activity in lung and aorta compared to the wild-type mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme is responsible for the cross-linking of collagen and elastin, and is required for vascular and diaphragmatic development during embryogenesis ?
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O Mus musculus
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 peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is responsible for the cross-linking of collagen and elastin, and is required for vascular and diaphragmatic development during embryogenesis Mus musculus ?
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O
-
 Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
LOX
-
 Mus musculus
lysyl oxidase
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 Mus musculus