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Literature summary for 1.4.3.1 extracted from

  • Sacchi, S.; Novellis, V.; Paolone, G.; Nuzzo, T.; Iannotta, M.; Belardo, C.; Squillace, M.; Bolognesi, P.; Rosini, E.; Motta, Z.; Frassineti, M.; Bertolino, A.; Pollegioni, L.; Morari, M.; Maione, S.; Errico, F.; Usiello, A.
    Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity (2017), Sci. Rep., 7, 46288 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by clozapine, chlorpromazine, haloperidol, bupropion, fluoxetine, and amitriptyline Homo sapiens
additional information not inhibited by clozapine, chlorpromazine, haloperidol, bupropion, fluoxetine, and amitriptyline Mus musculus
olanzapine
-
 Homo sapiens
olanzapine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-aspartate + H2O + O2 Mus musculus
-
 oxaloacetate + NH3 + H2O2
-
 ?
D-aspartate + H2O + O2 Homo sapiens
-
 oxaloacetate + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99489
-
-
Mus musculus Q0E9Q7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-aspartate + H2O + O2
-
 Mus musculus oxaloacetate + NH3 + H2O2
-
 ?
D-aspartate + H2O + O2
-
 Homo sapiens oxaloacetate + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
DDO
-
 Mus musculus
DDO
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
 in the presence of 0.004 mM FAD, pH and temperature not specified in the publication Mus musculus olanzapine
0.0231
-
 in the presence of 0.004 mM FAD, pH and temperature not specified in the publication Homo sapiens olanzapine